373403

Hh/Gli Antagonist, GANT61

InSolution, ≥95%

• 别名: InSolution Hh/Gli Antagonist, GANT61, 2,2ʹ-(2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl) bis(methylene) bis(N,N-dimethylaniline), NSC 136476, 2-((3-(2-(Dimethylamino)benzyl)-2-(4-pyridinyl)tetrahydro-1(2H)-pyrimidinyl)methyl)-N,N-dimethylaniline
• 经验公式（希尔记法）: C₂₇H₃₅N₅
• CAS号: 500579-04-4
• 分子量: 429.60
• MDL號碼: MFCD14635408
• 分類程式碼代碼: 51111800
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• SMILES 字串: CN(C)C1=CC=CC=C1CN2CCCN(CC3=CC=CC=C3N(C)C)C2C4=CC=NC=C4
• InChI: 1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3
• InChI 密鑰: KVQOGDQTWWCZFX-UHFFFAOYSA-N

说明

一般說明

A cell-permeable hexahydropyrimidine compound that displays similar pharmacological property as, but is structurally disctinct from, GANT58 (>Cat. No. 373400). While both compounds act as downstream Hedgehog (Hh) pathway-selective blockers and target Gli-mediated gene transactivation with similar potency (IC₅₀ ~5 µM) in SAG-stimulated Shh-L2 cells, GANT61 does exhibit better in vivo antitumor efficacy, presumably due to its superior pharmacokinetics, and only GANT61, but not GANT58, is shown to inhibit Gli DNA binding in HEK293 cells. The solid form of this compound (Cat. No. 373401) is also available.

生化／生理作用

Cell permeable: yes

Primary Target
Gli1 and Gli2

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

外觀

A 25 mM (2 mg/186 µL) solution of Hh/Gli Antagonist, GANT61 (Cat. No. 373401) in DMSO.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 188.6 °F - closed cup - (refers to pure substance)
• 閃點（°C）: 87 °C - closed cup - (refers to pure substance)