361548

GSK-3β Inhibitor VII

The GSK-3β Inhibitor VII, also referenced under CAS 99-73-0, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 别名: GSK-3β Inhibitor VII, α-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor
• 经验公式（希尔记法）: C₈H₆Br₂O
• CAS号: 99-73-0
• 分子量: 277.94
• MDL號碼: MFCD00000200
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated; protect from light
• 顏色: white
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• InChI: 1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
• InChI 密鑰: FKJSFKCZZIXQIP-UHFFFAOYSA-N

说明

一般說明

A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 0.5 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.

A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, selective, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 500 nM). Does not affect the activity of PKA even at concentrations as high as 100 µM.

生化／生理作用

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 0.5 µM against GSK-3β

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他說明

Conde, S., et al. 2003. J. Med. Chem.46, 4631.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS05
• 訊號詞: Danger
• 危險聲明: H314
• 防範說明: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• 危險分類: Skin Corr. 1B
• 儲存類別代碼: 8A - Combustible, corrosive hazardous materials
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable