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一般說明
Effective irreversible inhibitor of uPA, Factor Xa, and urokinase. Fluorophore allows direct monitoring of interactions of labeled enzyme. Does not inhibit tPA.
生化／生理作用
Cell permeable: no
Primary Target
UPA
UPA
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM for factor Xa
警告
Toxicity: Standard Handling (A)
重構
Following initial thaw, aliquot and refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
Reconstitute at 1 mg/ml in 10 mM HCl. Dilute with physiological buffers just prior to use.
其他說明
Bajaj, S.P., et al. 1992. Proc. Natl. Acad. Sci. USA89, 152.
Bergmeyer, H.V. 1984. Methods Enzym. Anal. 5, 375.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Bergmeyer, H.V. 1984. Methods Enzym. Anal. 5, 375.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Margaux R Audett et al.
Molecular biology of the cell, 33(1), ar1-ar1 (2021-10-28)
KNL1 is a large intrinsically disordered kinetochore (KT) protein that recruits spindle assembly checkpoint (SAC) components to mediate SAC signaling. The N-terminal region (NTR) of KNL1 possesses two activities that have been implicated in SAC silencing: microtubule (MT) binding and
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