推荐产品
品質等級
化驗
≥98% (TLC)
形狀
solid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
顏色
white
溶解度
DMSO: 5 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
InChI 密鑰
UIAYVIIHMORPSJ-UHFFFAOYSA-N
一般說明
A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 70 nM).
生化/生理作用
Cell permeable: yes
Primary Target
PDE 3
PDE 3
Product does not compete with ATP.
Reversible: no
Target IC50: 70 nM against PDE III
警告
Toxicity: Standard Handling (A)
重構
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
其他說明
Verghese, M.W., et al. 1995. J. Pharmacol. Exp. Ther. 272, 1313.
Christensen, S.B., and Trophy, T.J. 1994. Ann. Rep. Med. Chem. 29, 185.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
Christensen, S.B., and Trophy, T.J. 1994. Ann. Rep. Med. Chem. 29, 185.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
FEBS letters, 580(17), 4126-4130 (2006-07-11)
Overexpression of forkhead transcription factor FOXC2 in white adipose tissue (WAT) leads to a lean phenotype resistant to diet-induced obesity. This is due, in part, to enhanced catecholamine-induced cAMP-PKA signaling in FOXC2 transgenic mice. Here we show that rolipram treatment
Human reproduction (Oxford, England), 22(5), 1239-1246 (2007-02-17)
The use of hormones for controlled ovarian stimulation results in follicular heterogeneity, with oocytes at diverse stages of nuclear and cytoplasmic development. This study evaluated the impact of temporary nuclear arrest by a specific phosphodiesterase 3-inhibitor (PDE3-I), cilostamide, on nuclear
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