23-027-M

b-catenin Protein, activated, 10 µg

Activated, full length, recombinant human β-catenin. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using GSK-3a (Item # 14-492). For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.

• 别名: Catenin beta-1
• 分類程式碼代碼: 12352202
• eCl@ss: 32160405
• NACRES: NA.41

属性

• 生物源: human
• 品質等級: 100; 300
• 重組細胞: expressed in Sf21 cells
• 製造商／商標名: Upstate^®
• 技術: activity assay: suitable
• NCBI登錄號: NM_001904

说明

一般說明

β-catenin is a multifunctional protein; it is a central component of the cadherin cell adhesion complex, regulating the control of cell adhesion and plays an essential role in the Wingless/Wnt signaling pathway that governs cell fate in early embryogenesis. The regulation of β-catenin turnover in the cells is governed by its phosphorylation status which allows the targeting of ubiquitin-dependent proteolysis. Altered levels of protein expression as well as genetic mutations of β-catenin have been implicated in a number of human cancers.

N-terminal GST-tagged, recombinant human Smurf1 full length, expressed in E coli.

應用

Ubiquitination Cascade Comoponent: Substrate

外觀

Purified using immobilized metal affinity chromatography.

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: nwg