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Merck
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主要文件

219372

Sigma-Aldrich

组织蛋白酶G抑制剂I

≥98% (HPLC), solid, cathepsin G inhibitor, Calbiochem®

别名:

组织蛋白酶G抑制剂I

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About This Item

经验公式（希尔记法）:
C36H33N2O6P
CAS号:
429676-93-7
分子量:
620.63
MDL號碼:
MFCD28137715
分類程式碼代碼:
12352200
NACRES:
NA.77

产品名称

组织蛋白酶G抑制剂I, The Cathepsin G Inhibitor I, also referenced under CAS 429676-93-7, controls the biological activity of Cathepsin G. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

效力

53 nM IC50

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

DMSO: 5 mg/mL
methanol: soluble

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

[P](=O)(O)(O)C(c5c6c(ccc5)cccc6)C(=O)c1cc2c(cc1C(=O)N(C3CCN(CC3)C(=O)c4ccccc4)C)cccc2

InChI

1S/C36H33N2O6P/c1-37(28-18-20-38(21-19-28)35(40)25-11-3-2-4-12-25)36(41)32-23-27-14-6-5-13-26(27)22-31(32)33(39)34(45(42,43)44)30-17-9-15-24-10-7-8-16-29(24)30/h2-17,22-23,28,34H,18-21H2,1H3,(H2,42,43,44)

InChI 密鑰

GNOZQRKYZJSIPZ-UHFFFAOYSA-N

一般說明

组织蛋白酶G的有效，选择性，可逆，竞争性非肽抑制剂[IC50=53 nM，Ki=63 nM]。弱抑制胰凝乳蛋白酶（Ki = 1.5 µM），弱抑制凝血酶，Xa因子，IXa因子，纤溶酶，胰蛋白酶，类胰蛋白酶，蛋白酶3和人白细胞弹性蛋白酶（IC50 >100 µM）。
组织蛋白酶G的有效，选择性，可逆，竞争性非肽抑制剂（IC50 = 53 nM，Ki = 63 nM）。弱抑制胰凝乳蛋白酶（Ki = 1.5 µM），对凝血酶，Xa因子，IXa因子，纤溶酶，胰蛋白酶，类胰蛋白酶，蛋白酶3和人白细胞弹性蛋白酶（IC50 >100 µM）没有任何明显的抑制作用。

生化／生理作用

主要靶标
组织蛋白酶G
产物不与ATP竞争。
可逆性：是
细胞渗透性：否
靶标Ki：63 nM，对于组织蛋白酶G

包裝

用惰性气体包装

警告

毒性：标准处理（A）

重構

复溶后，等分并冷冻（-20°C）。储备液在-20°C条件下可稳定保存3个月。

其他說明

Greco, M.N., et al. 2002.J. Am. Chem. Soc.124, 3810.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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