217386

Carboxy-PTIO, Sodium Salt

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.

• 别名: Carboxy-PTIO, Sodium Salt, 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na
• 经验公式（希尔记法）: C₁₄H₁₆N₂O₄ · Na
• 分子量: 299.28
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥97% (TLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: dark blue
• 溶解度: HEPES Buffer: 0.4 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

一般說明

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO₂^-/NO₃^- with a rate constant of 1 x 10⁴ M^-1sec^-1. Prevents SIN-1 induced endothelial cell death. Has potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO₂^-/NO₃^- with a rate constant of 1 x 10⁴ M^-1sec^-1. Prevents SIN-1 induced endothelial cell death. Reported to have potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.

生化／生理作用

Cell permeable: no

Primary Target
Nitric oxide scavenging action

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.

其他說明

Ishii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
Amano, F., and Nova, J. 1995. FEBS Lett.368, 425.
Hogg, N., et al. 1995. Free Radical Res.22, 47.
Az-ma, T., et al. 1994. Life Sci.54, 185.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun.202, 923.
Akaike, T., et al. 1993. Biochemistry32, 827.
Yoshida, K., et al. 1993. Infect. Immun.61, 3552.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable