208721

ALLM

Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (K_i = 100 nM), and cathepsin L (K_i = 600 pM).

• 别名: ALLM, Calpain Inhibitor II
• 经验公式（希尔记法）: C₁₉H₃₅N₃O₄S
• CAS号: 110115-07-6
• 分子量: 401.56
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: >95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: off-white
• 溶解度: DMSO: 5 mg/mL; ethanol: 5 mg/mL; methanol: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1
• InChI 密鑰: RJWLAIMXRBDUMH-ULQDDVLXSA-N

说明

一般說明

A cell-permeable inhibitor of calpain I (K_i = 120 nM), calpain II (K_i = 230 nM), cathepsin B (K_i = 100 nM), and cathepsin L (K_i = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV⁺ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Cell permeable inhibitor of calpain I (K_i = 120 nM), calpain II (K_i = 230 nM), cathepsin B (K_i = 100 nM), and cathepsin L (K_i = 600 pM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV⁺ donors. Blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A weak inhibitor of proteasome.

生化／生理作用

Cell permeable: yes

Primary Target
calpain-1

Product does not compete with ATP.

Reversible: no

Target K_i: 120 nM, 230 nM, 100 nM, and 600 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively

警告

Toxicity: Standard Handling (A)

序列

N-Acetyl-Leu-Leu-Met

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Ravid, T., et al. 2000. J. Biol. Chem.275, 35840.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721.
Sarin, A., et al. 1994. J. Immunol.153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Banik, N.L., et al. 1992. Neurochem. Res.17, 797.
Koohmaraie, M. 1992. Biochemie74, 239.
Pinter, M., et al. 1992. Biochemistry31, 8201.
Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol.138, 24.
Sasaki, T., et al. 1990. J. Enzyme Inhib.3, 195.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable