203297-M

Bisindolylmaleimide IV

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM).

• 别名: Bisindolylmaleimide IV, Arcyriarubin A, 2,3- bis(1H-Indol-3-yl)maleimide, Ro 31-6233
• 经验公式（希尔记法）: C₂₀H₁₃N₃O₂
• CAS号: 119139-23-0
• 分子量: 327.34
• MDL號碼: MFCD00236432
• 分類程式碼代碼: 12352111

属性

• 品質等級: 100
• 化驗: ≥98% (TLC)
• 形狀: powder; solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: dark orange
• 溶解度: methanol: 10 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([nH]c2)cccc3
• InChI: 1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
• InChI 密鑰: DQYBRTASHMYDJG-UHFFFAOYSA-N

说明

一般說明

A cell-permeable potent and selective inhibitor of protein kinase C (IC₅₀ = 87 nM) and protein kinase A (IC₅₀ = 2.7 µM).

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM). Inhibits protein kinase A at much higher concentrations (IC₅₀ = 2.7 µM).

生化／生理作用

Primary Target
PKC

Target IC₅₀: 87 nM against protein kinase C

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable