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Merck
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Key Documents

19-144

Sigma-Aldrich

佛波醇12-十四酸酯13-乙酸酯,1MG

别名:

12-O-十四烷酰佛波醇13-乙酸酯, 4β,9α,12β,13α,20-五羟基噻吩-1,6-二烯-3-酮12-十四烷酸酯13-乙酸酯, PMA, TPA

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About This Item

分類程式碼代碼:
12352211
eCl@ss:
32160405
NACRES:
NA.41

形狀

solid

品質等級

製造商/商標名

Upstate®

技術

activity assay: suitable (kinase)

運輸包裝

wet ice

應用

佛波醇12-肉豆蔻酸酯13-乙酸酯可用作单核细胞系如 U937 和THP-1细胞分化的诱导剂。

生化/生理作用

佛波醇12-肉豆蔻酸酯13-乙酸酯是一种促肿瘤佛波酯。它通过激活蛋白激酶C(PKC)信号途径来调节各种过程,如基因转录、细胞生长和分化、凋亡、免疫反应和受体脱敏。它促进人单核细胞THP-1细胞分化为功能性巨噬细胞。

外觀

C36H56O8

儲存和穩定性

在-20°C下可保存2年

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

訊號詞

Danger

危險分類

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

儲存類別代碼

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3


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Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways.
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In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1.
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