189480-M

Autocamtide-2 Related Inhibitory Peptide

The Autocamtide-2 Related Inhibitory Peptide controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 别名: Autocamtide-2 Related Inhibitory Peptide, AIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL
• 经验公式（希尔记法）: C₆₄H₁₁₆N₂₂O₁₉
• 分子量: 1497.74
• 分類程式碼代碼: 12352202

属性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white
• 溶解度: water: 1 mg/mL
• 儲存溫度: −20°C

说明

一般說明

Non-phosphorylatable analog of Autocamptide-2 (Cat. No. 189475) that is a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC₅₀ = 40 nM) and is 50 and 500 times more potent than Ala²⁸⁶-CaM kinase II inhibitor, 281-301 (Cat. No. 208710) and KN-93 (Cat. No. 422708), respectively. Has no effect of PKA, PKC, and CaM kinase IV.

Non-phosphorylatable analog of Autocamtide-2 (Cat. No. 189475) that acts as a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC₅₀ = 40 nM). It is about 50 times more potent than [Ala²⁸⁶]-CaM kinase II Inhibitor, 281-301 (Cat. No. 208710). Has no effect on PKA, PKC, and CaM kinase IV. Blocks Ca²⁺-induced insulin secretion from electropermeabilized islets.

生化／生理作用

Target IC₅₀: 40 nM against calmodulin-dependent protein kinase II

警告

Toxicity: Standard Handling (A)

序列

H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH

其他說明

Bhat, H.S., et al. 2000. Biochem. Pharmacol.60, 1655.
Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun.212, 806.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable