169756

Antithrombin III, Human Plasma

Single-chain glycoprotein present in normal serum at about 23 mg/100 ml.

• 别名: Antithrombin III, Human Plasma, ATIII, Heparin cofactor, Factor Xa inhibitor
• CAS号: 90170-80-2
• MDL號碼: MFCD00166632
• 分類程式碼代碼: 12352202
• NACRES: NA.77

属性

• 品質等級: 100
• 形狀: solid
• 比活性: ≥5 units/mg protein
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 溶解度: water: soluble
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

一般說明

Single chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.

Single-chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.

生化／生理作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

單位定義

One unit is defined as the amount of antithrombin that will inhibit 1.0 unit of human plasma thrombin present in excess. Thrombin activity is measured using 500 µM tosyl-Gly-Pro-Arg-pNA as substrate in 100 mM Tris-HCl at 25°C, pH 8.2

外觀

Lyophilized from 100 mM sodium citrate buffer, 20 mM Tris-HCl, pH 8.3.

準備報告

Please refer to label for lot-specific volume prior to lyophilization.

分析報告

single band by SDS-PAGE

其他說明

Tsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable