14-404-M

ZAP-70 Protein, active, 20 µg

Active, recombinant, human, full length ZAP-70 containing a C-terminal His6 tag, for use in Kinase Assays.

• 别名: 70 kDa zeta-chain associated protein, SRK, Syk-related tyrosine kinase
• 分類程式碼代碼: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

属性

• 生物源: human
• 品質等級: 100
• 重組細胞: expressed in Sf21 cells
• 形狀: liquid
• 儲存期限: 6 mo.
• 分子量: M_w 70 kDa
• 製造商／商標名: Upstate^®
• 技術: activity assay: suitable (kinase)
• NCBI登錄號: NM_001079.3; NM_207519.1
• UniProt登錄號: P43403
• 儲存溫度: −20°C
• 基因資訊: human ... ZAP70(7535)

说明

一般說明

Research area: CELL SIGNALING

Product Source: expressed in Sf21 Recombinant, human, full length ZAP-70 containing a C-terminal His6-tag

Zeta-chain-associated protein kinase 70 (ZAP-70) is a cytoplasmic tyrosine kinase that consists of tandem SH2 (tSH2) domains at the beginning, linked with a long linker region, and a tyrosine kinase domain at the C-terminal end.

生化／生理作用

Protein Target: ZAP-70

Target Sub-Family: TK

Zeta-chain-associated protein kinase 70 (ZAP-70) plays a vital role in the development and function of T cells and natural killer cells. It interacts directly with the activated T-cell receptor and regulates downstream signals. In addition, ZAP-70 also mediates B-cell receptor (BCR) signaling. Mutations in ZAP-70 have been associated with severe combined immunodeficiency (SCID), chronic lymphocytic leukemia (CLL) , and the development of autoreactive T cells that attack the joints.

品質

routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) substrate peptide

外觀

Ni²⁺/NTA-agarose

儲存和穩定性

6 months at -20C

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1