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Merck
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主要文件

14-251-M

Sigma-Aldrich

p38α/SAPK2a Protein, active, 10 µg

Active, N-terminal GST tagged, recombinant, full length p38α/SAPK2a, for use in Kinase Assays.

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About This Item

分類程式碼代碼:
12352202
eCl@ss:
32160405
NACRES:
NA.41

生物源

human

品質等級

100

重組細胞

expressed in E. coli

分子量

Mw 67.7 kDa

製造商／商標名

Upstate®

技術

activity assay: suitable (kinase)

NCBI登錄號

NM_001315.1
NM_139012.1
NM_139013.1
NM_139014.1

UniProt登錄號

Q16539

基因資訊

human ... MAPK14(1432)

一般說明

N-terminal GST tagged, recombinant, full length p38α/SAPK2a
Product Source: expressed in E. coli

生化／生理作用

Protein Target: p38α/SAPK2a
Target Sub-Family: CMGC

包裝

Also available in 250μg size (2x125μg) - Call for pricing and availability. Please reference catalog number 14-251M when ordering the 250μg size.

品質

Routinely evaluated by phosphorylation of MBP

外觀

Glutathione-agarose

儲存和穩定性

6 months at -20°C

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H317

危險分類

Skin Sens. 1

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 2

分析证书(COA)

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Y N Doza et al.
FEBS letters, 364(2), 223-228 (1995-05-08)
A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress. Here we demonstrate that the stress-induced activation of the RK in human KB cells is accompanied by the phosphorylation of
A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.
Ben-Levy, R, et al.
The Embo Journal, 13, 3302-3311 (1994)
A Cuenda et al.
FEBS letters, 364(2), 229-233 (1995-05-08)
A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating kinase (RK) [Lee et al. (1994) Nature 372, 739-746]. We now show that one of these compounds (SB 203580) inhibits RK in vitro (IC50 = 0.6 microM)

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