推荐产品
生物源
rabbit
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
monoclonal
物種活性
human, mouse, rat
製造商／商標名
Upstate®
技術
western blot: suitable
同型
IgG
UniProt登錄號
運輸包裝
dry ice
目標翻譯後修改
phosphorylation (pSer218/pSer222)
基因資訊
human ... MAP2K1(5604)
特異性
磷酸化MEK1/MEK2
免疫原
含DpSMANpSF的肽，其中pS对应于人MEK1磷酸化氨基酸 218 和 222。
應用
使用经验证可用于WB的该抗磷酸化MEK1（Ser218/222）/MEK2（Ser222/226） 抗体来检测磷酸化MEK1（Ser218/222）/MEK2（Ser222/226） 。
研究子类别
MAP激酶
MAP激酶
研究类别
信号传导
信号传导
品質
通过免疫印迹对 B-Raf处理的PC-12细胞的 RIPA裂解液进行了常规评估
標靶描述
45kDa
聯結
替代：04-1017
外觀
0.1M Tris-甘氨酸，pH 7.4，0.15M NaCl，0.05％叠氮化钠，然后添加甘油至30％
形式：纯化
纯化蛋白A
儲存和穩定性
在-20°C下可保存2年
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1.
Gopalbhai, Kailesh, et al.
The Journal of Biological Chemistry, 278, 8118-8125 (2003)
Gonzalo L Gonzalez-Del Pino et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(36) (2021-09-03)
The RAF/MEK/ERK pathway is central to the control of cell physiology, and its dysregulation is associated with many cancers. Accordingly, the proteins constituting this pathway, including MEK1/2 (MEK), have been subject to intense drug discovery and development efforts. Allosteric MEK
C Hodge et al.
The Journal of biological chemistry, 273(47), 31327-31336 (1998-11-13)
Growth hormone (GH), a major regulator of normal body growth and metabolism, regulates cellular gene expression. The transcription factors Elk-1 and Serum Response Factor are necessary for GH-stimulated transcription of c-fos through the Serum Response Element (SRE). GH stimulates the
J C S Ho et al.
Oncogene, 35(7), 897-907 (2015-06-02)
HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) kills tumor cells broadly suggesting that conserved survival pathways are perturbed. We now identify nucleotide-binding proteins as HAMLET binding partners, accounting for about 35% of all HAMLET targets in a protein microarray
The 5-HT 2A serotonin receptor enhances cell viability, affects cell cycle progression and activates MEK-ERK1/2 and JAK2-STAT3 signalling pathways in human choriocarcinoma cell lines.
Oufkir T, Arseneault M, Sanderson JT, Vaillancourt C
Placenta null
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