04-151

Anti-IFNAR-1 Antibody, clone MARI-5A3

clone MARI-5A3, from mouse

• 别名: interferon (alpha, beta and omega) receptor 1, beta-type antiviral protein, alpha-type antiviral protein, Type I interferon receptor 1, Cytokine receptor family 2 member 1, interferon-beta receptor 1, Cytokine receptor class-II member 1, IFN-alpha-REC, i
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: MARI-5A3, monoclonal
• 物種活性: mouse
• 技術: flow cytometry: suitable; immunoprecipitation (IP): suitable; neutralization: suitable; western blot: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_034638
• UniProt登錄號: P33896
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: mouse ... Ifnar1(15975)

说明

一般說明

Interferon alpha/beta receptor 1 (IFNAR-1) is a single-pass type I membrane protein containing three fibronectin type-III domains and is a member of the type II cytokine receptor family. IFNAR-1 serves as an interferon receptor specific to interferons alpha and beta, a family of type I interferons critical to the promotion and the linking of adaptive and innate immune response. Type I interferons all bind to a heterodimeric receptor composed of two subunits, IFNAR-1 and IFNAR-2. The binding of the type I IFNs initializes tyrosine phosphorylation for several proteins such as; IFNR alpha/beta subunits, JAKs, STAT, and TYK2 proteins.

特異性

This antibody recognizes the extracellular domain of IFNAR-1.

免疫原

Recombinant protein corresponding to the extracellular domain of mouse IFNAR-1.

應用

Anti-IFNAR-1 Antibody, clone MARI-5A3 is an antibody against IFNAR-1 for use in FC, IP, WB, NEUT.

Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Neutralizing Assay: A previous lot was used by an independent laboratory in neutralization studies. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

品質

Evaluated by Flow Cytometry in BALB/c splenocytes.

Flow Cytometry Analysis: 5 µg of this antibody detected IFNAR-1 in BALB/c splenocytes.

標靶描述

63 kDa calculated

外觀

Format: Purified

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable