推荐产品
等級
certified reference material
品質等級
形狀
liquid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 1 mL
製造商／商標名
Cerilliant®
濃度
1.0 mg/mL in methanol
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
clinical testing
形式
single component solution
儲存溫度
−20°C
SMILES 字串
Nc1nnc(c(N)n1)-c2cccc(Cl)c2Cl
InChI
1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
InChI 密鑰
PYZRQGJRPPTADH-UHFFFAOYSA-N
基因資訊
human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
一般說明
Lamotrigine is an anticonvulsant approved for treatment of epilepsy and bipolar disorder. Sold under the trade name Lamictal®, this phenyltriazine analog also is used off-label for treatment of clinical depression. This Snap-N-Spike® Reference Solution is suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as forensic analysis and clinical toxicology.
應用
- Metabolic Impact in Bipolar Disorder: Lamotrigine is studied for its metabolic effects when used alongside antipsychotics in bipolar disorder management. The research, conducted through a network meta-analysis, provides insights into the mood stabilization and metabolic considerations during treatment (Kong et al., 2024).
- Forensic Application: Lamotrigine′s quantification in human plasma is critical in forensic science for ensuring accurate therapeutic monitoring and legal investigations. This application leverages HPLC-PDA techniques to analyze forensic samples, demonstrating the drug′s significance beyond clinical settings (Sánchez-Sellero et al., 2024).
- Advanced Drug Monitoring: A study has developed a method using LC-MS/MS for the simultaneous monitoring of lamotrigine among other antiepileptic drugs through dried blood and plasma spot sampling. This technique enhances the pharmacokinetic analysis and is pivotal for patient management in epilepsy treatment (Cao et al., 2024).
- Innovative Extraction Techniques: Research has introduced a molecularly imprinted polymer membrane for the selective extraction of lamotrigine, showcasing its utility in separating and quantifying this drug alongside other pharmaceuticals. This innovative approach benefits various biochemical assays and enhances drug analysis capabilities (Zhao et al., 2024).
- Enhanced Analytical Methodology: Lamotrigine′s determination in urine samples through a titania-based fabric phase sorptive extraction reflects its critical role in therapeutic drug monitoring. This method, paired with high-performance liquid chromatography, offers precise measurements essential for neurological disorder management (Ulusoy et al., 2024).
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Lamictal is a registered trademark of GlaxoSmithKline LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes,Central nervous system
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
其他客户在看
Crystal T Clark et al.
The American journal of psychiatry, 170(11), 1240-1247 (2013-11-05)
Little information is available on the need for dosage changes for lamotrigine in pregnant women with bipolar disorder. The authors present new data on serial serum levels of lamotrigine in pregnant patients on lamotrigine monotherapy. They also review the epilepsy
Stacey Shim et al.
The Journal of pharmacology and experimental therapeutics, 347(2), 487-496 (2013-08-30)
Carisbamate and lamotrigine are anticonvulsants that act on neuronal voltage-gated sodium channels. Carisbamate has shown antidepressant-like effects in animal models of depression, and lamotrigine is a mood stabilizer with a therapeutic effect in depressive episodes of patients with bipolar disorder.
Shai Sandalon et al.
Experimental eye research, 115, 47-56 (2013-07-03)
Voltage gated sodium channels (Nav), are proposed mediators of neuronal damage in ischemic and excitotoxicity disease models. We evaluated the neuroprotective effects of lamotrigine, a Nav blocker, in the acute and chronic rat ocular hypertension models. Additionally, expression of the
Chaitali Ghosh et al.
Epilepsia, 54(9), 1562-1570 (2013-07-20)
Brain drug bioavailability is regulated by the blood-brain barrier (BBB). It was recently suggested that cytochrome P450 (CYP) enzymes could act in concert with multidrug transporter proteins to regulate drug penetration and distribution into the diseased brain. The possibility that
Allyson K Friedman et al.
Science (New York, N.Y.), 344(6181), 313-319 (2014-04-20)
Typical therapies try to reverse pathogenic mechanisms. Here, we describe treatment effects achieved by enhancing depression-causing mechanisms in ventral tegmental area (VTA) dopamine (DA) neurons. In a social defeat stress model of depression, depressed (susceptible) mice display hyperactivity of VTA
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门