推荐产品
等級
certified reference material
品質等級
形狀
liquid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 1 mL
製造商/商標名
Cerilliant®
濃度
100 μg/mL in methanol
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
forensics and toxicology
格式
single component solution
儲存溫度
−20°C
SMILES 字串
CN1CC[C@]23[C@H]4Oc5c(O)ccc(C(O)[C@@H]1[C@@H]2C=C[C@@H]4O)c35
InChI
1S/C17H19NO4/c1-18-7-6-17-9-3-5-11(20)16(17)22-15-10(19)4-2-8(12(15)17)14(21)13(9)18/h2-5,9,11,13-14,16,19-21H,6-7H2,1H3/t9-,11-,13-,14?,16-,17-/m0/s1
InChI 密鑰
ISVKWTNAIRJURI-AKUCRQHZSA-N
一般說明
10-Hydroxymorphine is a potential impurity from the production of morphine pharmaceutical formulations. Morphine is a potent opiate analgesic drug used to relieve both acute and chronic severe pain. This Certified Snap-N-Spike® Solution is applicable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as impurity identification.
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相關產品
产品编号
说明
价格
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes
儲存類別代碼
3 - Flammable liquids
水污染物質分類(WGK)
WGK 2
閃點(°F)
49.5 °F - closed cup
閃點(°C)
9.7 °C - closed cup
Journal of pharmaceutical and biomedical analysis, 20(1-2), 179-183 (2000-03-07)
Separation of morphine and its oxidation products (10-S-hydroxymorphine, pseudomorphine and morphine N-oxide) by capillary zone electrophoresis in Tris-borate buffer in the presence of cyclodextrins was studied. Pyridoxine was used as an internal standard.
Morphine impurity with opioid activity is identified as 10 alpha-hydroxymorphine.
Pharmaceutical research, 7(11), 1205-1207 (1990-11-01)
Journal of pharmaceutical sciences, 92(3), 485-493 (2003-02-15)
Stability testing of morphine sulfate formulated with nonpareil sugar seeds (consisting of sucrose and starch) and fumaric acid revealed the formation of the three impurities 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine. 5-(Hydroxymethyl)-2-furfural was isolated via semipreparative HPLC utilizing volatile mobile phase constituents
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