推荐产品
等級
certified reference material
形狀
liquid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 1 mL
製造商／商標名
Cerilliant®
drug control
Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
濃度
1.0 mg/mL in methanol
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
clinical testing
格式
single component solution
儲存溫度
2-8°C
SMILES 字串
O=C1CN=C(C2=CC=CC=C2F)C3=CC(Cl)=CC=C3N1CCN(CC)CC
InChI
1S/C21H23ClFN3O.2ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;;/h5-10,13H,3-4,11-12,14H2,1-2H3;2*1H
InChI 密鑰
ZIIJJOPLRSCQNX-UHFFFAOYSA-N
一般說明
Flurazepam is a benzodiazepine, sold under the trade names Dalmane and Salmadorm for treament of mild to moderate insomnia. This analytical reference standard is suitable for many LC/MS or GC/MS applications from urine drug testing and clinical toxicology to forensic toxicology analysis.
應用
- Flurazepam in Sleep Research: Flurazepam, a benzodiazepine receptor agonist, is used in sleep epidemiology to explore its effects on sleep patterns and quality. This sedative-hypnotic is evaluated for its potential to improve sleep among various populations, contributing valuable insights into sleep medicine (Fernandez-Mendoza et al., 2024).
- Pharmacology and GABA Receptors: Studies involving Flurazepam help elucidate its mechanism as a GABAergic compound, particularly in the context of its interaction with GABA(A) receptors. This research is foundational in neuropharmacology, providing deeper understanding of how benzodiazepines modulate neuronal activity and contribute to their therapeutic and side effects (Sun et al., 2023).
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相關產品
产品编号
说明
价格
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes,Central nervous system
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
Feng-Zhi Bian et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 12(1), 56-61 (2010-02-02)
Benzodiazepines (BDZ) have many effects on various kinds of epilepsies, but long-term treatment with BDZ often leads to drug tolerance. This study aimed to seek drugs which can reverse the tolerance of flurazepam (FZP), and to explore the role of
M Dao Duong Thi et al.
The Journal of pharmacy and pharmacology, 61(3), 399-406 (2009-02-19)
To measure the metabolism and toxicity of 7-chloro-4-(cyclohexylmethyl)-1-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione (BNZ-1) and 4-cyclohexylmethyl-1-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione (BNZ-2), two new benzodiazepine analogues found to be effective against Leishmania amastigotes in vitro. The metabolism of BNZ-1 and -2 was investigated in isolated rat hepatocytes and rat liver
Julia Boyle et al.
Human psychopharmacology, 24(1), 61-71 (2008-11-06)
To evaluate the next-day residual effects of the novel hypnotic, gaboxadol, following bedtime dosing in healthy elderly subjects. Healthy women (N = 15) and men (N = 10) aged 65-79 years received a single bedtime (22:00 h) dose of gaboxadol
K Xiang et al.
Neuroscience, 157(1), 153-163 (2008-09-23)
One week oral flurazepam (FZP) administration in rats results in reduced GABA(A) receptor-mediated synaptic transmission in CA1 pyramidal neurons associated with benzodiazepine tolerance in vivo and in vitro. Since voltage-gated calcium channel (VGCC) current density is enhanced twofold during chronic
Kenichi Tsunoda et al.
International journal of geriatric psychiatry, 25(12), 1259-1265 (2010-01-08)
Benzodiazepines (BZDs) have been reported to cause negative impacts on body stability and cognitive functions, which in turn could result in lethal incidents, including falls, especially in the elderly. This fact notwithstanding, no systematic trial has evaluated the feasibility and
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