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Merck

E-016

Supelco

乙基-β-D-葡萄糖醛酸标准液

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式(希尔记法):
C8H14O7
CAS号:
分子量:
222.19
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

certified reference material

品質等級

形狀

liquid

特點

Snap-N-Spike®/Snap-N-Shoot®

包裝

ampule of 1 mL

製造商/商標名

Cerilliant®

濃度

100 μg/mL in methanol

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

forensics and toxicology

格式

single component solution

儲存溫度

−20°C

SMILES 字串

O[C@H]1[C@H](O)[C@@H](C(O)=O)O[C@@H](OCC)[C@@H]1O

InChI

1S/C8H14O7/c1-2-14-8-5(11)3(9)4(10)6(15-8)7(12)13/h3-6,8-11H,2H2,1H3,(H,12,13)/t3-,4-,5+,6-,8+/m0/s1

InChI 密鑰

IWJBVMJWSPZNJH-UQGZVRACSA-N

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一般說明

该认证标准物质广泛用于法医分析和临床毒理学应用,以确定血液中的酒精含量。

乙基-β-D-葡萄糖醛酸酯(EtG)是乙醇的一种水溶性、稳定的代谢物,被用作酒精滥用监测的常规生物标志物。极少部分乙醇降解为 EtG,可以在体液和头发中检测到。

應用

该认证标准溶液(CRM)还可作如下用途:

  • 通过超高效液相色谱(UHPLC)结合串联质谱(MS/MS)对人血浆和尿液样品中的不同酒精代谢物进行多残留分析
  • 使用优化的超临界液相色谱-串联质谱法(SFC-MS/MS)分离并定量分析人尿液样品中的高极性药物及其代谢物方法
  • 使用配对离子电喷雾质谱(PIESI-MS)联用高效液相色谱(HPLC)方法检测和测量尿样中的药物代谢物
  • 评估毛发样品的样品制备对超高效液相色谱-电喷雾电离-串联质谱法定量分析乙基-β-D-葡萄糖醛酸盐的影响
  • 通过台式气相色谱联用质谱联用(GC-MS)分析人类尿液样品中作为尿液生物标志物的乙基-β-D-葡萄糖醛酸酯

特點和優勢

  • 完全符合 ISO/IEC 17025 和 ISO 17034 认证
  • 附综合分析证书(CoA),包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
  • 通过实时稳定性研究严格测试,以确保准确性和保质期
  • 使用合格的精密天平进行重量准备,以确保最小不确定性
  • 氩气环境下火焰密封,装入安瓿以便长期保存
  • 提供方便的 DEA 豁免格式,以提高实验室效率

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

相關產品

产品编号
说明
价格

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

49.5 °F - closed cup

閃點(°C)

9.7 °C - closed cup


分析证书(COA)

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Sensitive detection of anionic metabolites of drugs by positive ion mode HPLC-PIESI-MS
Guo H, et al.
International Journal of Mass Spectrometry, 389, 14-25 (2015)
A simplified approach for determination of urinary ethyl glucuronide by gas chromatography-mass spectrometry
Ghosh S, et al.
Journal of analytical science and technology, 12, 1-9 (2021)
Jeremy N Matlow et al.
Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique, 19(3), e473-e482 (2012-11-06)
Ethyl glucuronide (EtG) is arising as a promising biomarker of heavy prenatal alcohol exposure, however its transfer across the human placenta is still unclear and is currently being investigated using the ex vivo placental perfusion model. This model allows for
J N Matlow et al.
Placenta, 34(4), 369-373 (2013-02-05)
Alcohol consumption during pregnancy can lead to Fetal Alcohol Spectrum Disorder (FASD), and because maternal self-reports are often unreliable, biomarkers of alcohol use are sometimes necessary to accurately determine fetal risk. Ethyl glucuronide (EtG), a direct metabolite of ethanol, has
Scott H Stewart et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 48(1), 83-87 (2012-09-28)
Hair ethyl glucuronide (EtG) is a promising biomarker of moderate-to-heavy alcohol consumption and may have utility in detecting and monitoring alcohol use in clinical populations where alcohol use is of particular importance. This study evaluated the relationship between hair EtG

商品

Review of clinically relevant ethanol metabolites and analytical method development for the analysis of ethyl glucuronide and ethyl sulfate in urine matrix.

Review of clinically relevant ethanol metabolites and analytical method development for the analysis of ethyl glucuronide and ethyl sulfate in urine matrix.

The method shown uses HILIC mode on an Ascentis® Express OH5 column to retain both analytes well, making it very likely to be more robust and reliable, as well as highly MS-friendly.

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