推荐产品
等級
certified reference material
形狀
liquid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 1 mL
製造商／商標名
Cerilliant®
濃度
1.0 mg/mL in acetonitrile
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
pharmaceutical (small molecule)
格式
single component solution
儲存溫度
−20°C
SMILES 字串
OC(CO[N+]([O-])=O)CO[N+]([O-])=O
InChI
1S/C3H6N2O7/c6-3(1-11-4(7)8)2-12-5(9)10/h3,6H,1-2H2
InChI 密鑰
ASIGVDLTBLZXNC-UHFFFAOYSA-N
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一般說明
1，3-二硝基甘油是药物血管扩张剂硝酸甘油的主要血浆代谢产物。该经认证的加标溶液®适用于药学研究或临床毒理学中基于色谱或质谱的应用。硝酸甘油用于治疗心脏病，例如心绞痛和慢性心力衰竭。
應用
- Population pharmacokinetics of nitroglycerin and of its two metabolites after a single 24-hour application of a nitroglycerin transdermal matrix delivery system: This study presents a comprehensive analysis on the population pharmacokinetics of nitroglycerin, focusing on its behavior and the behavior of its metabolites following the use of a transdermal delivery system. The findings contribute to understanding the systemic availability and action of nitroglycerin from such systems, which could be relevant for 1,3-Dinitroglycerin given its structural and functional similarities (Auclair et al., 1998).
- Novel pharmacokinetic modelling of transdermal nitroglycerin: This research explores advanced pharmacokinetic models that describe the absorption and action of nitroglycerin when administered through transdermal patches. Such models are crucial for developing effective transdermal delivery systems for similar compounds like 1,3-Dinitroglycerin (Auclair et al., 1998).
- Bioequivalence Comparison of Two Drug-in-Adhesive Transdermal Nitroglycerin Patches: This study compares the bioequivalence of two transdermal patches delivering nitroglycerin, highlighting the critical factors in the design and performance of transdermal systems that could similarly apply to 1,3-Dinitroglycerin (Harrison et al., 1996).
- Percutaneous absorption of 1,3-dinitroglycerin and a trial of pharmacokinetic analysis: Directly relevant to 1,3-Dinitroglycerin, this study examines its percutaneous absorption characteristics, offering insights into its potential applications in transdermal delivery systems (Ogiso et al., 1990).
- Analysis of solutions containing glutathione and inorganic nitrite: application to nitroglycerin metabolism studies: While primarily focused on nitroglycerin, this analysis could provide secondary insights into the metabolic pathways and interactions of 1,3-Dinitroglycerin with biomolecules like glutathione, which is crucial for understanding its pharmacological effects (Curry et al., 1987).
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相關產品
产品编号
说明
价格
訊號詞
Danger
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
35.6 °F - closed cup
閃點（°C）
2 °C - closed cup
B Auclair et al.
Pharmaceutical research, 15(4), 614-619 (1998-05-20)
To construct a pharmacokinetic (PK) model and to determine population PK parameters of nitroglycerin (GTN), 1,2-dinitroglycerin (1,2-GDN), and 1,3-dinitroglycerin (1,3-GDN). Data were obtained in thirty healthy volunteers following a single dose of a GTN reservoir transdermal patch. Blood samples were
B P Booth et al.
Anesthesia and analgesia, 78(5), 848-856 (1994-05-01)
Glyceryl trinitrate (GTN) is used to control arterial blood pressure during cardiopulmonary bypass (CPB) procedures, but its effects are often decreased during the period of extracorporeal support. The plasma and urine concentrations of GTN and glyceryl-1,2-dinitrate (1,2-GDN) and glyceryl-1,3-dinitrate (1,3-GDN)
Magnus Petersson et al.
Clinical physiology and functional imaging, 28(4), 229-234 (2008-04-04)
Patients with chronic heart failure (CHF) often require higher doses of nitroglycerin (glyceryl trinitrate, GTN) than patients with normal cardiac function to achieve a given haemodynamic goal. Two pathways leading to biotransformation of GTN have been characterized; a high-affinity pathway
B P Booth et al.
Canadian journal of physiology and pharmacology, 71(8), 629-632 (1993-08-01)
It has previously been shown that the vasodilatory response to glyceryl trinitrate (GTN) was decreased during hypothermic cardiopulmonary bypass. The purpose of these experiments was to determine the effect of temperature on GTN-induced relaxation and on GTN biotransformation in rabbit
T Kikkoji et al.
Pharmaceutical research, 8(10), 1231-1237 (1991-10-01)
The percutaneous penetration kinetics of the antianginal, nitroglycerin (GTN), and its primary metabolites, 1,2- and 1,3-glyceryl dinitrate (1,2- and 1,3-GDN), were evaluated in vitro, using full-thickness hairless mouse skin. GTN and the 1,2- and 1,3-GDNs were applied (a) in aqueous
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