推荐产品
形狀
powder
包裝
pkg of 1 × 5 mg (860488P-5mg)
製造商／商標名
Avanti Research™ - A Croda Brand 860488P
脂質類型
sphingolipids
bioactive lipids
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
CCCCCCCCCCCCCCC[C@@](O)([H])[C@@]([H])(N)CO
InChI
1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3
InChI 密鑰
OTKJDMGTUTTYMP-UHFFFAOYSA-N
一般說明
Safingol is a synthetic L-threo-stereoisomer of endogenous (D-erythro-) sphinganine. It acts as an inhibitor of protein kinase C and sphingosine kinase in vitro. Safingol is involved in ceramide generation and induction of apoptosis. It is known to stimulate antitumor activity of cisplatin.
應用
Safingol has been used as a substituent of dihydrosphingosine (dhSph) to increase the cytotoxic response in N-(4-hydroxyphenyl)retinamide (4-HPR)-resistant cells.
包裝
5 mL Amber Glass Screw Cap Vial (860488P-5mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A phase I clinical study of safingol followed by cisplatin: promising activity in refractory adrenocortical cancer with novel pharmacology
Carvajal RD, et al.
Journal of Clinical Oncology, 24(18), 13044-13044 (2006)
Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway
Coward J, et al.
Autophagy, 5(2), 184-193 (2009)
Andrej Kováčik et al.
Langmuir : the ACS journal of surfaces and colloids, 34(1), 521-529 (2017-12-13)
Ceramides (Cer) are key components of the skin permeability barrier. Sphingosine-based CerNS and dihydrosphingosine-based CerNdS (dihydroCer) have two chiral centers; however, the importance of the correct stereochemistry in the skin barrier Cer is unknown. We investigated the role of the
Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells
Apraiz A, et al.
BMC Cancer, 11(1), 477-477 (2011)
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