推荐产品
形狀
powder
包裝
pkg of 1 × 5 mg (860479P-5mg)
製造商／商標名
Avanti Research™ - A Croda Brand 860479P
脂質類型
sphingolipids
bioactive lipids
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@](NC(CC12C[C@H]3C[C@@H](C2)C[C@@H](C1)C3)=O)([H])CO[C@H](O4)[C@H](O)[C@@H](O)[C@@H](O)[C@H]4CO
生化／生理作用
Adamantyl galactosylceramide (adaGalCer), a glycosphingolipid (GSL) analog, modulates abnormal GSL turnover. It functions as an inhibitor and an alternative substrate to regulate cellular GSL metabolism in a particular manner. AdaGalCer blocks cell sulfatide synthesis and microsomal globotriaosyl ceramide (Gb3) synthesis. It reduces glucosylceramide (GlcCer) levels in normal and lysosomal storage disease (LSD) cells.
包裝
5 mL Amber Glass Screw Cap Vial (860479P-5mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Mustafa Kamani et al.
The Journal of biological chemistry, 286(24), 21413-21426 (2011-04-27)
Mammalian glycosphingolipid (GSL) precursor monohexosylceramides are either glucosyl- or galactosylceramide (GlcCer or GalCer). Most GSLs derive from GlcCer. Substitution of the GSL fatty acid with adamantane generates amphipathic mimics of increased water solubility, retaining receptor function. We have synthesized adamantyl
Adamantyl glycosphingolipids provide a new approach to the selective regulation of cellular glycosphingolipid metabolism
Kamani M, et al.
The Journal of Biological Chemistry, 286(24), 21413-21426 (2011)
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