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化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 100 μg (with stopper and crimp cap (860042P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (860042P-500ug))
製造商／商標名
Avanti Research™ - A Croda Brand 860042P
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[NH4+].[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C(=O)OC[C@H](COP([O-])(=O)O[C@H]1C(O)C(O)C(O)[C@@H](O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC
一般說明
16:0-d31-18:1 PI或1-棕榈酰基-d31-2-油酰基-sn-甘油-3-磷酸肌醇是氘代磷脂。该脂质由附着在棕榈酸和油酸上的磷脂酰肌醇基团组成。
氘化脂肪酸经历了α碳上的氘向羰基即C2位的交换，因此将是在该位置上完全氘化和部分氘化的化合物的混合物。
應用
16:0-d31-18:1 PI或1-棕榈酰基-d31-2-油酰基-sn-甘油-3-磷酸肌醇已用作内标：
- 在酵母脂质谱分析中
- 用于电喷雾电离串联质谱法（ESI-MS/MS）定量分析脂质
- 用于Bligh和Dyer方法从人支气管组织和上皮样品中提取脂质，并用于液相色谱-质谱（LC-MS）分析
生化／生理作用
磷脂酰肌醇（PI）在其羟基上被磷酸化，磷酸化的PI调节几种生物学过程，包括膜运输，蛋白质募集和自噬。
包裝
带塞子和压接盖的2 mL棕色血清瓶（860042P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（860042P-500ug）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
Nicole Zehethofer et al.
Chromatographia, 78(5-6), 403-413 (2015-03-10)
Airway epithelial cells play an important role in the pathogenesis of inflammatory lung diseases such as asthma, cystic fibrosis and COPD. Studies concerning the function of the lipid metabolism of the airway epithelium are so far based only on the
Nicholas J Blunsom et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(1), 158471-158471 (2019-06-08)
Phosphatidylinositol (PI) is a minor phospholipid with a characteristic fatty acid profile; it is highly enriched in stearic acid at the sn-1 position and arachidonic acid at the sn-2 position. PI is phosphorylated into seven specific derivatives, and individual species
Sarah Spiegel et al.
Nature reviews. Molecular cell biology, 4(5), 397-407 (2003-05-03)
The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are
Michael Maceyka et al.
Trends in cell biology, 22(1), 50-60 (2011-10-18)
The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized as a critical regulator of many physiological and pathophysiological processes, including cancer, atherosclerosis, diabetes and osteoporosis. S1P is produced in cells by two sphingosine kinase isoenzymes, SphK1 and SphK2. Many cells
Maria Makarova et al.
Current biology : CB, 30(3), 367-380 (2020-01-21)
Membrane function is fundamental to life. Each species explores membrane lipid diversity within a genetically predefined range of possibilities. How membrane lipid composition in turn defines the functional space available for evolution of membrane-centered processes remains largely unknown. We address
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