跳转至内容
Merck
所有图片(1)

Key Documents

更多文件

850546P

Avanti

MSDH

Avanti Polar Lipids 850546P, powder

别名:

(S)-O-methyl-serine dodecylamide hydrochloride

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C16H35ClN2O2
CAS号:
2074614-60-9
分子量:
322.91
分類程式碼代碼:
12161902
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

分子量

322.91 g/mol

包裝

pkg of 1 × 25 mg (850546P-25mg)

製造商／商標名

Avanti Polar Lipids 850546P

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[NH3+][C@@H](COC)C(NCCCCCCCCCCCC)=O.[Cl-]

相关类别

一般說明

O-methyl-serine-dodecylamide hydrochloride (MSDH) is a synthetic lysosomotropic detergent.

應用

MSDH is suitable is suitable to induce lysosomal membrane destabilization to investigate the mechanistic basis for Bax/Bak-mediated autophagic cell death.

生化／生理作用

O-methyl-serine-dodecylamide hydrochloride (MSDH) stimulates cell death. After apoptosis, it may activate procaspase 3-like proteases and cause partial lysosomal rupture.

包裝

5 mL Amber Glass Screw Cap Vial (850546P-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis
Fucho R, et al.
Journal of Hepatology, 61(5), 1126-1134 (2014)
Ana M Villamil Giraldo et al.
Langmuir : the ACS journal of surfaces and colloids, 32(50), 13566-13575 (2016-12-13)
Lysosomotropic detergents (LDs) selectively rupture lysosomal membranes through mechanisms that have yet to be characterized. A consensus view, currently, holds that LDs, which are weakly basic, diffuse across cellular membranes as monomers in an uncharged state, and via protonation in
Induction of cell death by the lysosomotropic detergent MSDH
Li W, et al.
Febs Letters, 470(1), 35-39 (2000)
Methylmercury and H2O2 provoke lysosomal damage in human astrocytoma D384 cells followed by apoptosis
Dare E, et al.
Free radical biology & medicine, 30(12), 1347-1356 (2001)
Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
Karch J, et al.
eLife, 6, e30543-e30543 (2017)

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门