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化驗
>99% (TLC)
形狀
powder
分子量
1115.26 g/mol
包裝
pkg of 1 × 1 g (850522P-1g)
pkg of 1 × 200 mg (850522P-200mg)
pkg of 1 × 25 mg (850522P-25mg)
製造商/商標名
Avanti Research™ - A Croda Brand 850522P
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])C[C@H]2OCCO[C@@H]4[C@@H](O)[C@H](O)[C@@H](O[C@H]5[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O5)[C@H](CO)O4)([H])C[C@H](OCCO[C@H]6[C@H](O)[C@@H](O)[C@H](O[C@@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](CO)O6)[C@@]
一般說明
Facade-EM is a two-dimensional amphiphile with hydrophobic and hydrophilic faces that has superior ability to stabilize integral membrane proteins. This new class of detergents represents a departure from traditional one-dimensional polar-head/nonpolar-tail molecules.
應用
Facade™EM (3α-hydroxy-7α,12α-di-((O-β-D-maltosyl)-2-hydroxyethoxy)-cholane) may be used:
- as a facial amphiphile detergent to purify protoxin-II (ProTx2)-voltage-sensor domain II (VSD2)-voltage-gated sodium (NavAb) channel
- as an additive in fluorescence quenching experiments of pentaene-SM 18
- to form isotropic bicelles with p75 for nuclear magnetic resonance (NMR) studies
生化/生理作用
Facades can be used for the crystallization of membrane proteins since they are considered as optimized membrane mimetics.
包裝
20 mL Clear Glass Screw Cap Vial (850522P-1g)
20 mL Clear Glass Screw Cap Vial (850522P-200mg)
5 mL Amber Glass Screw Cap Vial (850522P-25mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Facade is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
Faccade detergents as bicelle rim-forming agents for solution NMR spectroscopy
Nanotech. in Catalysis, 6(1), 93-103 null
Biochimica et biophysica acta, 1818(11), 2616-2622 (2012-06-16)
In membranes liquid disordered (l(d)) and liquid ordered (l(o)) domains can exist that differ in fluidity and function. L(o) areas are predominantly composed of cholesterol and sphingomyelin (SM). Study of the formation of such domains is hampered by a lack
Proceedings of the National Academy of Sciences of the United States of America, 110(13), E1203-E1211 (2013-03-13)
Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We have developed a family of steroid-based facial amphiphiles (FAs) that are structurally distinct from conventional detergents and previously developed FAs. The unique FAs stabilize MPs and
Designing facial amphiphiles for the stabilization of integral membrane proteins.
Angewandte Chemie (International ed. in English), 46(37), 7023-7025 (2007-08-11)
Nature, 557(7704), 196-201 (2018-05-04)
The movement of core-lipopolysaccharide across the inner membrane of Gram-negative bacteria is catalysed by an essential ATP-binding cassette transporter, MsbA. Recent structures of MsbA and related transporters have provided insights into the molecular basis of active lipid transport; however, structural
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