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描述
24(R/S),25-epoxycholesterol-d6
化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 1 mg (700048P-1mg)
製造商/商標名
Avanti Research™ - A Croda Brand
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
24(R/S),25-epoxycholesterol-d6 is a deuterated side-chain substituted oxysterol.
應用
24(R/S),25-epoxycholesterol-d6 has been used as a primary and deuterated surrogate sterol standard in the quantitative analysis of extracted sterol samples from cultured cells and tissues.
生化/生理作用
24(S),25-epoxycholesterol maintains cholesterol homeostasis. It modulates hepatic cholesterol metabolism in vivo. 24(S),25-epoxycholesterol is synthesized in the mevalonate pathway. It inhibits sterol regulatory element-binding protein (SREBP) activation.
Deuterated sterol plays a vital role in chemical and biochemical research. It is used as a mechanistic tracer to study the role of steroid hormones in the function and modulation of several physiological processes. Deuterated sterol is also used as reference standards for mass spectrometry. 24(R/S),25-epoxycholesterol-d6 is a deuterium labeled sterol.
包裝
5 mL Amber Glass Screw Cap Vial (700048P-1mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
24 (S), 25-epoxycholesterol: a messenger for cholesterol homeostasis
Brown AJ
The International Journal of Biochemistry & Cell Biology, 41(4), 744-747 (2019)
Site-specific synthesis and application of Deuterium-Labeled sterols
Muchalski H, et al.
Archive for Organic Chemistry (2017)
Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry
McDonald J, et al.
Test, 432, 145-170 (2007)
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