700047P

5α,6α-epoxycholestanol-d7

Avanti Polar Lipids

• 别名: cholestanol, 5α,6α-epoxy-d7
• 经验公式（希尔记法）: C₂₇H₃₉O₂D₇
• CAS号: 127685-38-5
• 分子量: 409.70
• 分類程式碼代碼: 12352100
• NACRES: NA.25

属性

• 化驗: >99% (TLC)
• 形狀: powder
• 包裝: pkg of 1 × 1 mg (700047P-1mg)
• 製造商／商標名: Avanti Polar Lipids
• 運輸包裝: dry ice
• 儲存溫度: −20°C

说明

一般說明

5α,6α-epoxycholestanol (5α,6α-EC) is generated by cholesterol epoxidation. 5α,6α-epoxycholestanol-d7 is a deuterated derivative of 5α,6α-EC. It is catabolized by the enzyme cholesterol-5,6-epoxide hydrolase (ChEH) enzyme to 3β,5α,6β-triol.

應用

5α,6α-epoxycholestanol-d7 has been used as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondrial samples. It may be used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis of plasma samples.

生化／生理作用

5α,6α-epoxycholestanol (5α,6α-EC) is a liver X receptor (LXR) antagonist. 5α,6α-EC is employed in anticancer treatments. It impairs redox state and affects atherogenesis. The levels of 5α,6α-EC are elevated in hypercholesterolemia. It mediates steroid receptor coactivator (SRC) recruitment.

包裝

5 mL Amber Glass Screw Cap Vial (700047P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全信息

• 儲存類別代碼: 11 - Combustible Solids