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Merck

QBD10918

Sigma-Aldrich

m-dPEG®48-amine

>95% (HPLC)

别名:

m-PEG48-amine, mPEG-amine, mPEG2000-amine, mPEG48-NH2

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About This Item

经验公式(希尔记法):
C97H197NO48
分子量:
2145.58
MDL號碼:
分類程式碼代碼:
12352116
NACRES:
NA.22

化驗

>95% (HPLC)

形狀

solid or viscous liquid

反應適用性

reaction type: Pegylations

聚合物結構

shape: linear
functionality: monofunctional

運輸包裝

ambient

儲存溫度

−20°C

特點和優勢

m-dPEG48-amine is a methyl-terminated PEG amine compound. The PEG is a water-soluble, single molecular weight PEG product with a discrete chain length (dPEG). This dPEG linker is 146 atoms (173.1 Å) long, a monodisperse equivalent of a PEG2000. Carboxylic acids and their active esters react with the amino terminus to form amide bonds. Also, the amino terminus reacts with aldehydes and ketones, forming Schiff bonds, which are reducible to secondary amines. Uses for m-dPEG48-amine include modification of acid-functionalized surfaces and free carboxylic acid groups on biomolecules.

法律資訊

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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George Badescu et al.
Bioconjugate chemistry, 25(3), 460-469 (2014-02-12)
Many clinically used protein therapeutics are modified to increase their efficacy. Example modifications include the conjugation of cytotoxic drugs to monoclonal antibodies or poly(ethylene glycol) (PEG) to proteins and peptides. Monothiol-specific conjugation can be efficient and is often accomplished using

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