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化驗
>95% (HPLC)
形狀
solid or viscous liquid
反應適用性
reaction type: Pegylations
聚合物結構
shape: linear
functionality: monofunctional
運輸包裝
ambient
儲存溫度
−20°C
特點和優勢
m-dPEG48-amine is a methyl-terminated PEG amine compound. The PEG is a water-soluble, single molecular weight PEG product with a discrete chain length (dPEG). This dPEG linker is 146 atoms (173.1 Å) long, a monodisperse equivalent of a PEG2000. Carboxylic acids and their active esters react with the amino terminus to form amide bonds. Also, the amino terminus reacts with aldehydes and ketones, forming Schiff bonds, which are reducible to secondary amines. Uses for m-dPEG48-amine include modification of acid-functionalized surfaces and free carboxylic acid groups on biomolecules.
法律資訊
Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Bioconjugate chemistry, 25(3), 460-469 (2014-02-12)
Many clinically used protein therapeutics are modified to increase their efficacy. Example modifications include the conjugation of cytotoxic drugs to monoclonal antibodies or poly(ethylene glycol) (PEG) to proteins and peptides. Monothiol-specific conjugation can be efficient and is often accomplished using
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