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品質等級
化驗
≥98%
顏色
off-white to yellow
mp
164-166 °C (lit.)
儲存溫度
2-8°C
SMILES 字串
O=C1C=C(Oc2ccc3ccccc3c12)c4ccccc4
InChI
1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H
InChI 密鑰
OUGIDAPQYNCXRA-UHFFFAOYSA-N
基因資訊
rat ... Gabra2(29706)
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一般說明
β-萘黄酮是一种多环芳烃。
應用
β-萘黄酮已用于:
- 作为芳烃受体激动剂,阐明其对转基因细胞色素 P450 1A1(cyp1a)报告基因的斑马鱼胚胎中 Cyp1A1 表达的影响
- 作为 AhR 激动剂,处理原代正常人表皮角质形成细胞(NHEKs),通过蛋白质印迹法研究芳香烃受体(AhR)激活
- 确定其对肌营养不良蛋白(Dp)71 表达的影响
- 刺激 Cre 重组酶的表达,并删除侧翼为 loxP 序列的等位基因
生化/生理作用
β-萘黄酮是人体中芳烃受体(AhR)的外源配体。它是 I 期解毒酶(CYP)和 II 期酶(UDP-GTs)和 NAD(P)H 依赖性醌氧还原酶-1(NQO1)的诱导物。它还诱导细胞色素 P450(Cyp1a)的表达。BNF 通过改变转录因子的结合来抑制 Duchenne 肌营养不良基因(肌营养不良蛋白(Dp)71) 的表达。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice
Scientific data, 3(4), 160008-160008 (2016)
Cyp1a reporter zebrafish reveals target tissues for dioxin
Aquatic Toxicology (Amsterdam, Netherlands), 134, 57-65 (2013)
beta-naphthoflavone interferes with cyp1c1, cox2 and IL-8 gene transcription and leukotriene B4 secretion in Atlantic cod (Gadus morhua) head kidney cells during inflammation
Fish & Shellfish Immunology, 54(1), 128-134 (2016)
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 157(2), 172-182 (2012-11-28)
CYP1A is involved in the metabolism of diverse chemicals, including polycyclic aromatic hydrocarbons and alkylated-PAHs, as a first line of detoxification mechanism. First, we identified and characterized the CYP1A gene from the marine medaka, Oryzias melastigma. O. melastigma CYP1A (Om-CYP1A)
Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
Journal of medicinal chemistry, 54(6), 1539-1554 (2011-02-25)
商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
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