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品質等級
產品線
ReagentPlus®
化驗
99%
mp
155-157 °C (lit.)
SMILES 字串
NC(=O)c1ccncc1
InChI
1S/C6H6N2O/c7-6(9)5-1-3-8-4-2-5/h1-4H,(H2,7,9)
InChI 密鑰
VFQXVTODMYMSMJ-UHFFFAOYSA-N
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應用
异烟酰胺（吡啶-4-甲酰胺）可作为合成以下物质的杂环结构单元：
它还可用作共晶试剂（co-former）,与活性药物成分（API）一起制备共晶体。
- 潜在抗结核剂4-氧代-1,3-噻嗪烷-3-基异烟酰胺衍生物。
- 通过合成氨基磷酸酯配体制备的用于各种生物活性研究的异烟酰胺有机锡 (IV) 复合物。
- 2-(羟基亚氨基)-N-(吡啶-3-基)乙酰胺的双吡啶鎓异烟酰胺衍生物，其是一种强效活化剂沙林
它还可用作共晶试剂（co-former）,与活性药物成分（API）一起制备共晶体。
法律資訊
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Gareth Arnott et al.
Organic letters, 10(14), 3089-3092 (2008-06-17)
Treatment of N-arylisonicotinamides with trifluoromethanesulfonic anhydride triggers intramolecular nucleophilic attack of the aryl ring on the 4-position of the pyridinium intermediate. The products are spirocyclic dihydropyridines which can be converted to valuable spirocyclic piperidines related to biologically active molecules such
Rodrigo A de Souza et al.
European journal of medicinal chemistry, 45(11), 4863-4868 (2010-08-21)
Complexes of the type trans-[PdX(2)(isn)(2)] {X = Cl (1), N(3) (2), SCN (3), NCO (4); isn = isonicotinamide} were synthesized and evaluated for in vitro antimycobacterial and antitumor activities. The coordination mode of the isonicotinamide and the pseudohalide ligands was
Jemma Senczyszyn et al.
Organic letters, 15(8), 1922-1925 (2013-04-04)
On treatment with acylating or sulfonylating agents, N-alkenyl pyridine carboxamides (N-pyridinecarbonyl enamines) undergo a dearomatizing cyclization initiated by pyridine acylation and followed by intramolecular trapping of the resulting pyridinium cation. The products are spirocyclic dihydropyridines which may be further elaborated
Sarah Boyd et al.
Journal of pharmaceutical sciences, 99(9), 3779-3786 (2010-07-29)
The solubility and crystal growth of the 1:1 cocrystal between benzoic acid and isonicotinamide from 95% ethanol was studied through the creation of a ternary phase diagram at differing temperatures and turbidity measurements. From the solubility measurements thermodynamic properties of
Shaun R Stauffer et al.
Bioorganic & medicinal chemistry letters, 17(6), 1788-1792 (2007-01-30)
A series of low-molecular weight 2,6-diamino-isonicotinamide BACE-1 inhibitors containing an amine transition-state isostere were synthesized and shown to be highly potent in both enzymatic and cell-based assays. These inhibitors contain a trans-S,S-methyl cyclopropane P(3) which bind BACE-1 in a 10s-loop
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