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Merck

A0424

Sigma-Aldrich

枸橼酸阿尔维林 柠檬酸盐

别名:

N-乙基-3,3′-二苯二丙胺

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About This Item

经验公式(希尔记法):
C20H27N · C6H8O7
CAS号:
分子量:
473.56
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

形狀

powder

品質等級

SMILES 字串

OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CCCc1ccccc1)CCCc2ccccc2

InChI

1S/C20H27N.C6H8O7/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-8,11-14H,2,9-10,15-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI 密鑰

RYHCACJBKCOBTJ-UHFFFAOYSA-N

基因資訊

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應用

Used for studies of pharmacological activity including:
  • Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans
  • Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome
  • Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
  • Drug effects viewed from a signal transduction network perspective
  • Enhanced cytotoxic effect of proteasome inhibitor MG132
  • Mechanism of action on phasic smooth muscles

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析证书(COA)

Lot/Batch Number

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Mehmet Arhan et al.
World journal of gastroenterology, 10(15), 2303-2304 (2004-07-20)
Alverine citrate is a commonly used smooth muscle relaxant agent. A MEDLINE search on January 2004 revealed only 1 report implicating the hepatotoxicity of this agent. A 34-year-old woman was investigated because of the finding of elevated liver function tests
A Abysique et al.
Alimentary pharmacology & therapeutics, 13(4), 561-566 (1999-04-24)
Alverine citrate is commonly used in the treatment of painful affections of the colon. To determine whether alverine citrate acts on the vagal sensory endings. Unitary recordings were performed at the level of the vagal fibres in the nodose ganglion
S A Mitchell et al.
Alimentary pharmacology & therapeutics, 16(6), 1187-1195 (2002-05-29)
Alverine citrate has been used in the treatment of irritable bowel syndrome for many years. To compare the efficacy and safety of a new formulation of alverine citrate, a 120-mg capsule, with placebo given three times daily for 12 weeks.
A M Coelho et al.
The Journal of pharmacy and pharmacology, 53(10), 1419-1426 (2001-11-08)
Serotonin (5-HT) is considered as a major mediator causing hyperalgesia and is involved in inflammatory reactions and irritable bowel syndrome. Alverine citrate may possess visceral antinociceptive properties in a rat model of rectal distension-induced abdominal contractions. This study was designed
[Dynamics of clinical symptoms and indices of visceral sensitivity in patients with the irritated bowels syndrome treated with meteospasmyl].
P A Makarchuk et al.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (1)(1), 25-29 (2005-07-05)

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