936529

(S,R,S)-AHPC-CO-PEG4-C2-acid

≥95%

• 别名: (S)-18-[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidine-1-carbonyl]-19,19-dimethyl-16-oxo-4,7,10,13-tetraoxa-17-azaicosanoic acid, (S)-18-[[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidin-1-yl]carbonyl]-19,19-dimethyl-16-oxo-4,7,10,13-tetraoxa-17-azaicosanoic acid, L-Prolinamide, N-(15-carboxy-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• 经验公式（希尔记法）: C₃₄H₅₀N₄O₁₀S
• CAS号: 2172820-12-9
• 分子量: 706.85
• MDL號碼: MFCD32693336
• 分類程式碼代碼: 12352106
• NACRES: NA.22

属性

• ligand: VH032
• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder or crystals
• 顏色: White to Beige
• 儲存溫度: 2-8°C
• SMILES 字串: C([C@@H](NC(CCOCCOCCOCCOCCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

说明

應用

(S,R,S)-AHPC-CO-PEG4-C2-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

其他說明

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable