925004

E7820-PEG₁-NH₂ hydrochloride

• 别名: N-(2-(2-Aminoethoxy)ethyl)-3-(N-(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl)benzamide, Crosslinker−E3 Ligase ligand conjugate hydrochloride, DCAF15 protein degrader building block
• 经验公式（希尔记法）: C₂₁H₂₃N₅O₄S · xHCl
• 分子量: 441.50 (free base basis)
• NACRES: NA.22

属性

• ligand: E7820
• 品質等級: 100
• 反應適用性: reactivity: carboxyl reactive; reagent type: ligand-linker conjugate
• 官能基: amine
• 儲存溫度: 2-8°C

说明

應用

Protein degrader building block E7820-PEG₁-NH₂ hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC^® (proteolysis-targeting chimeras) research. This conjugate contains a DCAF15-recruiting ligand E7820 (SML2950), a PEG linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Protein Degrader Building Blocks

Technology Spotlight: DCAF15 Degrader Building Blocks for Targeted Protein Degradation

其他說明

In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable