923818

N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide

• 别名: Coumarin alkyne CoLDR probe
• 经验公式（希尔记法）: C₁₇H₁₅NO₄
• 分子量: 297.31
• NACRES: NA.22

属性

• 反應適用性: reagent type: chemical modification reagent; reaction type: click chemistry
• 品質等級: 100
• 官能基: (Alkyne)
• 儲存溫度: 2-8°C
• SMILES 字串: O=C1OC2=CC(OCC(C(NCCC#C)=O)=C)=CC=C2C=C1

说明

應用

N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide is a proteomic cysteine probe. As described in Reddi et al, the Nir London lab developed a-substituted N-alkynyl-methacrylamides for covalent ligand directed release chemistry (CoLDR). CoLDR represents a new type of acrylamide-based electrophiles for targeted covalent inhibitor discovery and design. Specifically this CoLDR probe is a coumarin derivative with a terminal alkyne for click chemistry.

其他說明

Chemical Biology Tools

Click Chemistry Reagents

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable