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Merck

913901

Sigma-Aldrich

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) dimethacrylate

average Mn ~14,600

别名:

F-108 dimethacrylate, PEG-PPG-PEG, Pluronic dimethacrylate

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About This Item

线性分子式:
C4H5O[C2H4O]x[C3H6O]y[C2H4O]zC4H5O2
分類程式碼代碼:
12162002
NACRES:
NA.23

形狀

powder

品質等級

分子量

average Mn ~14,600

包含

≤1500 ppm MeHQ

顏色

off-white to yellow

儲存溫度

−20°C

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應用

Poloxamers are nonionic, triblock copolymers containg a central hydrophobic chain of poly(propylene glycol) (PPG) and two terminal hydrophilic chains of poly(ethylene glycol) (PEG). Due to their amphiphilic structure, poloxamer solutions feature temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of poloxamers are liquid at low temperature and form a gel at higher temperature, in a reversible process. This characteristic has allowed for these materials to be used as drug carriers for most routes of administration including oral, topical, intranasal, ocular, and parenteral. Methacrylate-modified derivatives are most commonly used as thermosensitive hydrogels for drug delivery and 3D bioprinting applications. After casting or printing, the material can be crosslinked to preserve the hydrogel structure.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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High-Throughput Printing via Microvascular Multinozzle Arrays.
Hansen C J, et al.
Advanced Materials, 25(1), 96-10 (2013)
Application of thermoreversible pluoronic F-127 gels in Pharmaceutical formulations.
Escobar-Chavez J J, et al.
J. Pharm. Pharm. Sci., 9(3), 339-358 (2006)
Self-Assembly of Pluronic F127 Diacrylate in Ethylammonium Nitrate: Structure, Rheology, and Ionic Conductivity before and after Photo-Cross-Linking.
Lopez Barron C R, et al.
Macromolecules, 49(14), 5179-5189 (2016)
Smart hydrogels for 3D bioprinting.
Wang S, et al.
International Journal of Bioprinting, 1(1), 3-14 (2015)
Michael Müller et al.
Biofabrication, 7(3), 035006-035006 (2015-08-12)
Bioprinting is an emerging technology in the field of tissue engineering as it allows the precise positioning of biologically relevant materials in 3D, which more resembles the native tissue in our body than current homogenous, bulk approaches. There is however

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