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Merck

909157

Sigma-Aldrich

Alkyne functionalized gelatin

degree of substitution > 80%

别名:

Alkyne-functionalized gelatin, Clickable gelatin

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About This Item

分類程式碼代碼:
43211915
NACRES:
NA.23

描述

Degree of substitution: >80% by TNBS method
NMR: Conforms to structure

形狀

powder

顏色

white to pale yellow

儲存溫度

2-8°C

一般說明

Due to its biodegradablity and biocompatibility, gelatin is routinely used in hydrogels for biomedical applications such as drug delivery, tissue engineering, and 3D bioprinting. Gelatin-based hydrogels are synthesized by the crosslinking of functionalized gelatins. Depending on the identity of the functional groups, several different processes can be used to synthesize crosslinked gelatin hydrogels, including radical-based (either thermal or photochemical) and click chemistry methods. Alkyne-functionalized gelatin can be used in the synthesis of hydrogel using click chemistry with either azide or thiol substrates.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Thiol-yne ′click′/coupling chemistry and recent applications in polymer and materials synthesis and modification.
Lowe AB, et al.
Polymer, 55, 5517-5549 (2014)
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels.
Yue K, et al.
Biomaterials, 73, 254-271 (2015)
Vinh X Truong et al.
Biomacromolecules, 16(7), 2246-2253 (2015-06-10)
In this study, we present a method for the fabrication of in situ forming gelatin and poly(ethylene glycol)-based hydrogels utilizing bioorthogonal, strain-promoted alkyne-azide cycloaddition as the cross-linking reaction. By incorporating nitrobenzyl moieties within the network structure, these hydrogels can be
Gelatin hydrogels via thiol-ene chemistry.
Russo L, et al.
Monatshefte fur Chemie / Chemical Monthly, 147, 587-592 (2016)
Sandeep T Koshy et al.
Advanced healthcare materials, 5(5), 541-547 (2016-01-26)
Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell-responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for

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