901906

2-二环己基膦基-2′,6′-二甲氧基联苯基

95%

• 别名: S Phos, SPhos
• 经验公式（希尔记法）: C₂₆H₃₅O₂P
• CAS号: 657408-07-6
• 分子量: 410.53
• MDL號碼: MFCD05861611
• 分類程式碼代碼: 12161600
• NACRES: NA.22

属性

• 化驗: 95%
• 形狀: powder or crystals
• 反應適用性: reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Heck Reaction; reaction type: Hiyama Coupling; reaction type: Negishi Coupling; reaction type: Sonogashira Coupling; reaction type: Stille Coupling; reaction type: Suzuki-Miyaura Coupling; reagent type: catalyst; reaction type: Cross Couplings; reagent type: ligand
• mp: 164-166 °C (lit.); 165.5 °C
• 官能基: phosphine
• SMILES 字串: COc1cccc(OC)c1-c2ccccc2P(C3CCCCC3)C4CCCCC4
• InChI: 1S/C26H35O2P/c1-27-23-17-11-18-24(28-2)26(23)22-16-9-10-19-25(22)29(20-12-5-3-6-13-20)21-14-7-4-8-15-21/h9-11,16-21H,3-8,12-15H2,1-2H3
• InChI 密鑰: VNFWTIYUKDMAOP-UHFFFAOYSA-N

说明

一般說明

SPhos [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

應用

SPhos may be used as a ligand in the following processes:

• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.
• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.
• Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.

Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation

用于Suzuki-Miyaura偶联反应的高度通用配体； 芳基氯、受阻联芳基、杂联芳基。

法律資訊

使用涉及的专利号：US 6307087；EP 1097158；JP 5758844；CA 2336691

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable