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86734

Sigma-Aldrich

1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸

≥97.0% (CHN)

别名:

DOTA

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About This Item

经验公式（希尔记法）:
C16H28N4O8 · xH2O
CAS号:
60239-18-1
分子量:
404.42 (anhydrous basis)
Beilstein:
1186987
MDL號碼:
MFCD00068657
分類程式碼代碼:
12352005
PubChem物質ID:
57653192
NACRES:
NA.22

品質等級

100

化驗

≥97.0% (CHN)

形狀

powder

SMILES 字串

OC(=O)CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O

InChI

1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)

InChI 密鑰

WDLRUFUQRNWCPK-UHFFFAOYSA-N

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應用

1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA)是一种大环络合剂。
  • 它已用于通过螯合64Cu放射性同位素进行碳纳米管生物偶联物的放射性标记。
  • DOTA可被N-羟基琥珀酰亚胺基活化，进而与单克隆抗体偶联，用于临床放射免疫治疗。
  • 它可与钆形成配合物用作MRI造影剂。
  • DOTA肽偶联物的金属配合物可用作治疗用放射性药物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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分析证书(COA)

Lot/Batch Number
BCCD5753
BCBV9132
BCBP6598V
BCBP6599V
BCBL2779V

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The aim of this work was to investigate the use of 13 C-labelled acetoacetate and β-hydroxybutyrate as novel hyperpolarized substrates in the study of cardiac metabolism. [1-13 C]Acetoacetate was synthesized by catalysed hydrolysis, and both it and [1-13 C]β-hydroxybutyrate were
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Scientific reports, 7(1), 5961-5961 (2017-07-22)
Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imaging of EGFR expression in tumours may aid in selection of optimal cancer therapy. The
B Klaan et al.
Der Radiologe, 59(8), 710-721 (2019-07-10)
The imaging of chondral pathologies is an essential part in the work-up of acute and chronic joint diseases. Besides conventional MR imaging, CT and MR arthrography are well-established methods in evaluating articular cartilage. The application of these techniques requires knowledge
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The journal of physical chemistry. B, 117(11), 3145-3153 (2013-02-28)
We present the first example of chemoselective site-specific spin labeling of a monomeric protein with two spectroscopically orthogonal spin labels: a gadolinium(III) chelate complex and a nitroxide radical. A detailed analysis of the performance of two commercially available Gd(III) ligands
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European journal of nuclear medicine and molecular imaging, 40(3), 439-449 (2012-11-28)
Radionuclide imaging of insulin-like growth factor type 1 receptor (IGF-1R) expression in tumours might be used for selection of patients who would benefit from IGF-1R-targeted therapy. We have previously shown the feasibility of IGF-1R imaging using the Affibody molecule (111)In-DOTA-His(6)-Z(IGF1R:4551).
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