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![γ-[（炔丙基）-亚氨基]-ATP 钠盐](/deepweb/assets/sigmaaldrich/product/structures/394/730/00e7a2cd-6683-4939-9d87-4c35480b1186/640/00e7a2cd-6683-4939-9d87-4c35480b1186.png)
化驗
≥95% (HPLC)
品質等級
形狀
solid
反應適用性
reaction type: click chemistry
溶解度
10 mM Tris-HCl, pH 7.5: soluble
運輸包裝
wet ice
儲存溫度
−20°C
SMILES 字串
O[C@@H]([C@H]1O)[C@@H](COP(O)(OP(O)(OP(O)(O)=O)=O)=O)O[C@@H]1N2C=NC3=C2N=CN=C3NCC#C
InChI
1S/C13H18N5O13P3/c1-2-3-14-11-8-12(16-5-15-11)18(6-17-8)13-10(20)9(19)7(29-13)4-28-33(24,25)31-34(26,27)30-32(21,22)23/h1,5-7,9-10,13,19-20H,3-4H2,(H,24,25)(H,26,27)(H,14,15,16)(H2,21,22,23)/t7-,9-,10-,13?/m1/s1
InChI 密鑰
MUOIWXPACQCYQC-RJNFYWFKSA-N
應用
N6-炔丙基-ATP适用于蛋白质的体外AMPylation以及RNA的体外聚腺苷酸化。可以使用Cu(I)催化的点击化学方法处理所得的炔烃官能化的蛋白质或RNA，以连接叠氮化物标记的分子。这提供了诸如引入用于纯化任务的生物素基团，引入用于检测的荧光基团或与其他叠氮化物官能化的生物分子交联的选择。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Markus Grammel et al.
Journal of the American Chemical Society, 133(43), 17103-17105 (2011-09-29)
Protein AMPylation is an emerging post-translational modification, which plays key roles in bacterial pathogenesis and cell biology. Enzymes with AMPylation activity, referred to as AMPylators, have been identified in several bacterial pathogens and eukaryotes. To facilitate the study of this
A new chemical handle for protein AMPylation at the host-pathogen interface.
Malgorzata Broncel et al.
Chembiochem : a European journal of chemical biology, 13(2), 183-185 (2012-01-04)
Markus Grammel et al.
Chembiochem : a European journal of chemical biology, 13(8), 1112-1115 (2012-04-20)
A versatile "clickable" nucleoside: Metabolic labeling of cells is useful in studying the dynamics of biological molecules. N(6) pA can be utilized by all three mammalian RNA polymerases, as well as poly(A) polymerase. Because of its alkyne modification, RNA labeled
Eui Kyoung Jang et al.
Nucleic acids research, 47(17), e102-e102 (2019-07-19)
Terminal deoxynucleotidyl transferase (TdT), which mediates template-independent polymerization with low specificity for nucleotides, has been used for nucleotide extension of DNA oligomers. One concern is that it is difficult to control the number of incorporated nucleotides, which is a limitation
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