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Merck

79380

Sigma-Aldrich

光气 溶液

~20% in toluene

别名:

Carbon oxychloride, Carbonyl chloride, Phosgen

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About This Item

线性分子式:
COCl2
CAS号:
分子量:
98.92
Beilstein:
1098367
MDL號碼:
分類程式碼代碼:
12352101
PubChem物質ID:
NACRES:
NA.22

形狀

solution

品質等級

反應適用性

reaction type: Carbonylations

濃度

~20% in toluene

雜質

≤300 mg/kg benzene

官能基

chloro

儲存溫度

2-8°C

SMILES 字串

ClC(Cl)=O

InChI

1S/CCl2O/c2-1(3)4

InChI 密鑰

YGYAWVDWMABLBF-UHFFFAOYSA-N

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一般說明

Phosgene is an organic chemical compound widely used as a chlorinating agent, carbonylating agent, and dehydrating agent in organic synthesis for the synthesis of various compounds.

應用

Phosgene solution (~20% in toluene) can be used as a reagent in the synthesis of multiblock copolymers via multiple coupling reactions. It is also used in the activation of the hydroxyl groups in poly(ethylene glycol) diol (PEG diol) to synthesize linear multifunctional poly(ethylene glycol).

訊號詞

Danger

危險分類

Acute Tox. 2 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT SE 1 Inhalation - STOT SE 3

標靶器官

Central nervous system, Lungs

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

39.2 °F - closed cup

閃點(°C)

4 °C - closed cup

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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分析证书(COA)

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Pradip Kundu et al.
Analytical chemistry, 84(10), 4594-4597 (2012-04-11)
Phosgene is a very toxic gas, which was used as a chemical weapon in World War I, and is currently widely used in industrial processes. So far, no any phosgene fluorescent sensor has been reported. In this study, we report
Rui Liu et al.
Scientific reports, 2, 813-813 (2012-12-12)
Identifying a critical transition and its leading biomolecular network during the initiation and progression of a complex disease is a challenging task, but holds the key to early diagnosis and further elucidation of the essential mechanisms of disease deterioration at
Wen-Li Li et al.
Inhalation toxicology, 23(13), 842-852 (2011-11-01)
The principal acute mode of action of inhaled phosgene gas is related to an increase alveolar fluid exudation under pathologic conditions. This paper considers some aspects in modeling phosgene-induced acute lung injury (ALI) in an acute rat bioassay and whether
Hong-li Chen et al.
Journal of applied toxicology : JAT, 33(1), 71-77 (2011-08-06)
Phosgene is a poorly water-soluble gas penetrating the lower respiratory tract which can induce acute lung injury characterized by a latent phase of fatal pulmonary edema. Pulmonary edema caused by phosgene is believed to be a consequence of oxidative stress
Christopher Grainge et al.
Clinical toxicology (Philadelphia, Pa.), 48(6), 497-508 (2010-09-21)
Phosgene is a substance of immense importance in the chemical industry. Because of its widespread industrial use, there is potential for small-scale exposures within the workplace, large-scale accidental release, or even deliberate release into a built-up area. This review aims

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