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Merck

765511

Sigma-Aldrich

官能化金纳米粒子COOH

20 nm diameter, carboxylic acid functionalized, PEG 5000 coated, OD 50, dispersion in H2O

别名:

Au NP COOH, 金胶体

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About This Item

分類程式碼代碼:
12162002
NACRES:
NA.23

材料

PEG 5000

品質等級

形狀

dispersion in H2O
nanoparticles

包裝

poly bottle of 1 mL

外徑

50

直徑

20 nm

pH值

6.0-8.0 (25 °C)

溶解度

water: miscible

密度

1.00 g/cm3

λmax

520 nm

官能基

carboxylic acid

儲存溫度

2-8°C

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相关类别

一般說明

Carboxylic acid functionalized GNPs form conjugates with various protein molecules due to the electrostatic attraction between negatively charged carboxylate groups and positively charged amino groups of protein.

應用

Carboxylic acid functionalized, PEG 5000 coated, OD 50, and H2O dispersed gold nanoparticles can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.
AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique. It may also be used in the immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.
The carboxylic acid group binds with various proteins and can be used in targeted drug delivery and gene therapy.
功能化颗粒已被广泛用于研究纳米颗粒的细胞摄取和靶向药物递送

特點和優勢

Decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. The PEG increases the stability of the nanoparticles and prevents agglomeration.

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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访问文档库

Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
Zhang X, et al.
International journal of nanomedicine, 6, 2071-2071 (2011)
Nishima Wangoo et al.
Journal of colloid and interface science, 323(2), 247-254 (2008-05-20)
We report a novel strategy for the synthesis of aqueous stable, carboxylated gold nanoparticles (GNPs) by using glutamic acid as the reducing agent. The ratio of chloroaurate ions, AuCl(-)(4) to glutamic acid was optimized in the reaction medium to obtain
Recent advances in nanoparticle-based lateral flow immunoassay as a point-of-care diagnostic tool for infectious agents and diseases
Banerjee R and Jaiswal A
Analyst, 143(9), 1970-1996 (2018)
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)

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