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材料
PEG 5000
品質等級
形狀
dispersion in H2O
nanoparticles
包裝
glass bottle of 1 mL
外徑
50
直徑
10 nm
pH值
6.0-8.0 (25 °C)
溶解度
water: miscible
密度
1.00 g/cm3
λmax
520 nm
官能基
amine
儲存溫度
2-8°C
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一般說明
直径范围为 2-200nm 的金纳米颗粒（AuNP） 在多个领域得到应用。它们具有优异的生物相容性和诱人的物理化学特性。金纳米颗粒上的聚（乙二醇）（PEG）表面涂层有助于减少蛋白质吸附，减少与细胞的非特异性相互作用，并大幅改善这些纳米颗粒的药代动力学并减少纳米颗粒的聚集。PEG层密度与AuNP曲率成反比。较小的 AuNP 上可以实现更致密的涂层。涂有 PEG 5000 的 AuNP具有最高的胶体稳定性。以聚乙二醇 （PEG） 为配体或载体分子的胺基功能化 GNP 与 siRNA 形成偶联物，在 RNAi 技术中非常有用。由于粘附在细胞膜上，因此它可用于靶向药物递送应用中的细胞和细胞内靶向，也可用于生物分布研究。
應用
下面列出了其他几项具体应用：
- AuNP粘附在细胞膜上，因此可用于靶向药物递送应用中的细胞和细胞内靶向，也可用于生物分布研究。
- AuNP还可用于光热疗法和放射疗法。
- 金纳米粒子的建议应用包括：用于癌症治疗的药物递送剂、涂料、塑料、纳米线、纳米纤维、纺织品、催化剂应用。
- 它们还可以用于携带通过抑制特定癌症基因来对抗人类前列腺癌细胞的 siRNA。
功能化颗粒已广泛用于研究纳米颗粒的细胞摄取和靶向药物递送。
特點和優勢
- 与带正电的 GNP 相连的带负电的 siRNA-PEG 复合物在还原性胞质环境中很容易被裂解，从而使 siRNA 释放到胞质中。
- PEG涂层降低细胞毒性并提高GNP的效率。PEG增加了纳米颗粒的稳定性并防止了团聚。
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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