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形狀
solid
饋電比
lactide:glycolide 50:50
分子量
PEG average Mn 5,000
PLGA Mn 7,000
average Mn 12,000 (total)
降解時間
1-4 weeks
轉變溫度
Tg 24 °C
Tm 38-43 °C
蛋白質二硫鍵異構酶
<2.0
儲存溫度
2-8°C
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一般說明
應用
特點和優勢
- 良好的生物相容性、低免疫原性和良好的降解性。
- 通过改变嵌段共聚物链段的尺寸可以轻松调节其性能,以适合特定应用。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
No data available
閃點(°C)
No data available
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One of the common difficulties with intravenous drug delivery is low solubility of the drug. The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated interest is the formation of drug-loaded micelles.
Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.
Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a given time period.
Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.
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