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756482

Sigma-Aldrich

氯[(三-TERT-三丁基膦)-2-(2-氨基联苯)]钯(II)

别名:

氯[（三-叔-丁基膦）-2-（2-氨基联苯）]钯（II）

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About This Item

经验公式（希尔记法）:
C24H37ClNPPd
CAS号:
1375325-71-5
分子量:
512.40
MDL號碼:
MFCD21608496
分類程式碼代碼:
12161600
PubChem物質ID:
329766544
NACRES:
NA.22

形狀

solid

品質等級

100

特點

generation 2

反應適用性

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings

mp

167-170 °C (decomposition)

官能基

phosphine

SMILES 字串

NC1=C(C2=CC=CC=C2[Pd]Cl)C=CC=C1.CC(C)(C)P(C(C)(C)C)C(C)(C)C

InChI

1S/C12H10N.C12H27P.ClH.Pd/c13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;1-10(2,3)13(11(4,5)6)12(7,8)9;;/h1-6,8-9H,13H2;1-9H3;1H;/q;;;+1/p-1

InChI 密鑰

ZVSLIOFJVMRWHJ-UHFFFAOYSA-M

相关类别

一般說明

P（t-Bu）3 Pd G2（氯[(三-叔-丁基膦）-2-（2-氨基联苯基）]钯（II））是一种含有联苯基配体的第二代（G2）预催化剂。该产品可参与多种钯催化的交叉偶联反应，C-C、C-N和C-O键形成反应，以及Suzuki-Miyaura偶联反应。它在室温下在弱磷酸盐或碳酸盐碱存在下可产生活性Pd催化剂。研究人员已经提出将其用作芳基卤化物（溴化物和氯化物）的Stille反应中的活性催化剂。

應用

P（t-Bu）3 Pd G2（氯[（三-叔-丁基膦）-2-（2-氨基联苯）]钯（II），Pd/P（t-Bu）3）可用作以下研究中的催化剂：
  • 通过芳基氯化物的交叉偶联反应，进行空间位阻联芳基（四邻位-取代）的合成。
  • 芳基氯化物的Stille交叉偶联反应。
  • 通过Stille交叉偶联反应合成氯代肽I。
  • Heck反应。
  • Negishi交叉偶联反应。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
SHBM5348
SHBL4565
SHBL0980
SHBK3497
SHBJ1716

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Adam F Littke et al.
Journal of the American Chemical Society, 124(22), 6343-6348 (2002-05-30)
Pd/P(t-Bu)(3) serves as an unusually reactive catalyst for Stille reactions of aryl chlorides and bromides, providing solutions to a number of long-standing challenges. An unprecedented array of aryl chlorides can be cross-coupled with a range of organotin reagents, including SnBu(4).
Gregory C Fu
Accounts of chemical research, 41(11), 1555-1564 (2008-10-25)
Metal-catalyzed coupling reactions of aryl electrophiles with organometallics and with olefins serve as unusually effective tools for forming new carbon-carbon bonds. By 1998, researchers had developed catalysts that achieved reactions of aryl iodides, bromides, and triflates. Nevertheless, many noteworthy challenges

商品

Scale-Up Guide: Buchwald-Hartwig Amination Reaction

All of the preformed catalysts used in the kit are air and moisture stable complexes in their commercially available form. Once activated by base under the reaction conditions they become sensitive to air. To best enable scale-up success, the use of standard Schlenk technique is recommended.

Scale-Up Guide: Buchwald-Hartwig Amination Reaction

All of the preformed catalysts used in the kit are air and moisture stable complexes in their commercially available form. Once activated by base under the reaction conditions they become sensitive to air. To best enable scale-up success, the use of standard Schlenk technique is recommended.

Scale-Up Guide: Buchwald-Hartwig Amination Reaction

All of the preformed catalysts used in the kit are air and moisture stable complexes in their commercially available form. Once activated by base under the reaction conditions they become sensitive to air. To best enable scale-up success, the use of standard Schlenk technique is recommended.

KitAlysis™ C-N (Buchwald-Hartwig) High-Throughput Screening Kit

All contents in the foil bag are weighed, plated, packed, and sealed in a glove box under nitrogen.

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