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Merck

679011

Sigma-Aldrich

2-(二苯基膦)对苯二甲酸 1-甲基 4-五氟苯基二酯

97%

别名:

1-甲基-4-(五氟苯基)-2-(二苯基膦)-1,4-苯二羧酸酯

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About This Item

经验公式(希尔记法):
C27H16F5O4P
分子量:
530.38
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.22

化驗

97%

形狀

solid

反應適用性

reaction type: click chemistry

mp

109-111 °C

儲存溫度

−20°C

SMILES 字串

COC(=O)c1ccc(cc1P(c2ccccc2)c3ccccc3)C(=O)Oc4c(F)c(F)c(F)c(F)c4F

InChI

1S/C27H16F5O4P/c1-35-27(34)18-13-12-15(26(33)36-25-23(31)21(29)20(28)22(30)24(25)32)14-19(18)37(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-14H,1H3

InChI 密鑰

OURNVXDJALDDIG-UHFFFAOYSA-N

應用

  • Staudinger ligation reagent for the conjugation of amine and azide containing compounds or biomolecules.
  • The amine functionalized molecule first reacts with the phosphine through the activated pentafluorophenyl ester.The azide-molecule is then reacted with the newly labeled phosphine to form the iminophosphorane, and the aza-ylide is subsequently captured by the methyl ester to yield the covalent conjugated product.
2-(Diphenylphosphino)terephthalic acid 1-methyl 4-pentafluorophenyl diester Staudinger Ligation Probe and Target
The Staudinger Ligation: A High-Yield, Chemoselective, and Mild Synthetic Method

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说明
价格

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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E Saxon et al.
Science (New York, N.Y.), 287(5460), 2007-2010 (2000-03-17)
Selective chemical reactions enacted within a cellular environment can be powerful tools for elucidating biological processes or engineering novel interactions. A chemical transformation that permits the selective formation of covalent adducts among richly functionalized biopolymers within a cellular context is

商品

Chemoselective ligation strategies are a key success factor for chemical biology research. Ligation techniques open pathways to fully synthetic large peptides and even proteins.

The reaction between an azide and a phosphine forming an aza-ylide was discovered almost a century ago by Nobel Prize laureate Herrmann Staudinger.

The reaction between an azide and a phosphine forming an aza-ylide was discovered almost a century ago by Nobel Prize laureate Herrmann Staudinger.

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