化驗
98%
形狀
solid
mp
54-58 °C (lit.)
SMILES 字串
CC(C)(C)C1=CC(=O)C=CC1=O
InChI
1S/C10H12O2/c1-10(2,3)8-6-7(11)4-5-9(8)12/h4-6H,1-3H3
InChI 密鑰
NCCTVAJNFXYWTM-UHFFFAOYSA-N
一般說明
2-叔 -丁基-1,4-苯醌（TBQ、TBBQ、TBQ、BuBQ、BQ、 叔 -丁基- p -醌）是 1,4-苯醌衍生物。它是食品添加剂丁基羟基茴香醚 (BHA) 的主要代谢产物。据报道，TBQ 在人单核细胞白血病 U937 细胞中具有很强的细胞毒性。TBQ 是 2- 叔 -丁基对苯二酚 (TBHQ) 的氧化产物。研究证实 TBQ 诱导慢性粒细胞白血病 (CML) 细胞凋亡和细胞增殖抑制。研究发现，它与溶菌酶的结合相互作用现介于 BHA 和 TBHQ 之间。据报道，它是使用30% H2O2经过钛超氧催化氧化 2- 叔 -丁基苯酚水溶液合成的。TBQ 是 PLA-TBHQ 薄膜（聚乳酸）中 TBHQ 分解产生的主要新生化合物之一。
應用
2--叔 -丁基-1，4-苯醌可用于氮杂三恶烷 [8] 环烯的合成。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
2-tert-butyl-1, 4-benzoquinone Induces Apoptosis in Chronic Myeloid Leukemia Cells Resistant to Imatinib via Inducing Caspase-Dependent Bcr-Abl Downregulation.
Shi X, et al.
Medicinal Chemistry, 4, 784-790 (2014)
R Kahl et al.
Toxicology, 59(2), 179-194 (1989-12-01)
The synthetic antioxidant butylated hydroxyanisole (BHA) stimulates superoxide formation in rat liver microsomes up to 10-fold. This stimulation is prevented by the monooxygenase inhibitor metyrapone and does not occur when NADH is consumed instead of NADPH indicating that metabolic activation
W H Kalus et al.
Environmental health perspectives, 102(1), 96-99 (1994-01-01)
We examined t-butylhydroquinone (t-BHQ) and t-butylquinone (t-BuQ), two of the major microsomal metabolites of the synthetic antioxidant butylated hydroxyanisole (BHA), for their ability to react with the xenobiotic arylamines aniline and N-methylaniline. A number of substances were isolated by thin-layer
Azatrioxa [8] circulenes: Planar Anti-Aromatic Cyclooctatetraenes.
Nielsen CB, et al.
Chemistry (Weinheim An Der Bergstrasse, Germany), 19(12), 3898-3904 (2013)
P A Schilderman et al.
Carcinogenesis, 16(3), 507-512 (1995-03-01)
The food additive butylated hydroxyanisole (BHA) has been shown to induce gastrointestinal hyperplasia in rodents by an unknown mechanism. The relevance of this observation for human risk assessment is not clear. We therefore analysed the effect of BHA and its
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