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化驗
99.995% trace metals basis
形狀
powder, crystals or chunks
pH值
2.5-3.5 (20 °C, 50 g/L)
mp
155-157 °C (dec.) (lit.)
密度
1.67 g/mL at 25 °C (lit.)
SMILES 字串
Cl.NO
InChI
1S/ClH.H3NO/c;1-2/h1H;2H,1H2
InChI 密鑰
WTDHULULXKLSOZ-UHFFFAOYSA-N
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應用
作为反应物用于制备：
- 作为甲流病毒M2质子通道有效抑制剂和结构探针的有机硅烷胺
- 作为拓扑异构酶I抑制剂以及潜在抗肿瘤剂的Lamellarin D类似物
- 作为用于预防早产的前列腺素F2α受体抑制剂的Azapeptide宫缩抑制剂
- 与吲哚啉-2-酮螺旋稠合的噻唑烷酮，作为结核分枝杆菌蛋白酪氨酸磷酸酶B的有效且选择性抑制剂
- 口服生物可利用的靶向Lys554基于喹啉的抗糖尿病二肽基肽酶IV抑制剂
- 与一氧化氮供体作为抗病毒剂的嘧啶核苷衍生物
- 靶向腺苷A2A受体和腺苷转运蛋白用于神经保护的苄基腺苷化合物
- 作为香草素受体TRPV1的抑制剂并在尿失禁的大鼠膀胱测压模型中具有改善潜力的萘酚衍生物
生化／生理作用
MAO 抑制剂;抑制血小板聚集。
訊號詞
Warning
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
標靶器官
spleen
儲存類別代碼
4.1A - Other explosive hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Carine B Bourguet et al.
Journal of medicinal chemistry, 54(17), 6085-6097 (2011-07-22)
The prostaglandin-F2α (PGF2α) receptor (FP) was targeted to develop tocolytic agents for inhibiting preterm labor. Azabicycloalkane and azapeptide mimics 2-10 were synthesized based on the (3S,6S,9S)-indolizidin-2-one amino acid analogue PDC113.824 (1), which was shown to modulate FP by a biased
Salvatore Cananzi et al.
Bioorganic & medicinal chemistry, 19(16), 4971-4984 (2011-07-26)
A novel 5-oxa-6a,8-diazaindeno[2,1-b]phenanthren-7-one scaffold was designed and synthesized as an active analogue of the cytotoxic marine alkaloid Lamellarin D. The design was based on molecular modeling of the site of interaction of Lamellarin D with DNA-topoisomerase I cleavable complex, whereas
Jun Wang et al.
Journal of the American Chemical Society, 133(35), 13844-13847 (2011-08-09)
We describe the use of organosilanes as inhibitors and structural probes of a membrane protein, the M2 proton channel from influenza A virus. Organosilane amine inhibitors were found to be generally as potent as their carbon analogues in targeting WT
Hironobu Maezaki et al.
Bioorganic & medicinal chemistry, 19(15), 4482-4498 (2011-07-12)
Dipeptidyl peptidase IV (DPP-4) inhibition is a validated therapeutic option for type 2 diabetes, exhibiting multiple antidiabetic effects with little or no risk of hypoglycemia. In our studies involving non-covalent DPP-4 inhibitors, a novel series of quinoline-based inhibitors were designed
Shi, J.; et al.
Chinese Chemical Letters = Zhongguo Hua Xue Kuai Bao, 22, 899-899 (2011)
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