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一般說明
4-氯-1-丁醇是一种烷化剂，是活性药物成分中的遗传毒性杂质之一。通过分光光度法对4-氯-1-丁醇和Reichardt染料的反应进行监测，从而测定药物中的遗传毒性杂质。
應用
在GC-MS技术中，4-氯-1-丁醇作为内标已被用于活性药物成分中遗传毒性杂质的分析。
其他說明
含四氢呋喃和 HCl
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 3 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
安全危害
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
96.8 °F - closed cup
閃點（°C）
36 °C - closed cup
個人防護裝備
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
其他客户在看
Koki Harigaya et al.
Chemical & pharmaceutical bulletin, 62(4), 395-398 (2014-04-04)
The analysis of genotoxic impurities (GTIs) in active pharmaceutical ingredients (APIs) is a challenging task. The target detection limit (DL) in an API is typically around 1 ppm (1 µg/g API). Therefore, a sensitive and selective analytical method is required for their
Damion K Corrigan et al.
The Journal of pharmacy and pharmacology, 61(4), 533-537 (2009-03-21)
Alkylating agents are potentially genotoxic impurities that may be present in drug products. These impurities occur in pharmaceuticals as by-products from the synthetic steps involved in drug production, as impurities in starting materials or from in-situ reactions that take place
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