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About This Item
经验公式（希尔记法）:
C14H12N2O2
CAS号:
分子量:
240.26
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
形狀:
solid
化驗:
97%
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化驗
97%
形狀
solid
mp
228-230 °C (lit.)
官能基
ester
SMILES 字串
CCOC(=O)c1cc2c(cn1)[nH]c3ccccc23
InChI
1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3
InChI 密鑰
KOVRZNUMIKACTB-UHFFFAOYSA-N
基因資訊
human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRG2(2566)
rat ... Gabra2(29706)
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訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
B K Koe et al.
European journal of pharmacology, 90(1), 97-102 (1983-05-20)
Ethyl beta-carboline-3-carboxylate (beta CCE), a benzodiazepine antagonist, was found to increase basal levels of cyclic GMP in rat cerebellum. beta CCE also augmented the elevation of cyclic GMP concentrations induced by isoniazid, in contrast to diazepam which blocked this effect
B Elgoyhen et al.
The Journal of pharmacology and experimental therapeutics, 261(2), 534-539 (1992-05-01)
The effects of two beta-carbolines, methyl 6,7-dimethoxy-4-ethyl-beta- carboline-3-carboxylate (DMCM) and ethyl beta-carboline-3-carboxylate (beta CCE) were assayed on rat aortic rings precontracted with different agonists. The beta-carbolines tested induced a concentration-dependent (2-200 microM) relaxation of aortic rings precontracted with 30 mM
M Katsura et al.
European journal of pharmacology, 298(1), 71-77 (1996-02-29)
Effect of exposure of primary cultured cerebral cortical neurons to ethyl beta-carboline-3-carboxylate (beta-CCE) on the function of benzodiazepine receptors was studied. Exposure of neurons to beta-CCE (0.1-10 microM) decreased the binding of [3H]flunitrazepam to extensively washed membrane fractions in a
J G Wettstein et al.
Pharmacology, biochemistry, and behavior, 44(3), 633-641 (1993-03-01)
The respiratory and behavioral effects of the benzodiazepine receptor (BZR) inverse agonist ethyl-beta-carboline-3-carboxylate (beta-CCE) were determined alone and in combination with buspirone, lorazepam, flumazenil, and SR 95195 in rhesus monkeys. For the respiratory studies, one group of monkeys inhaled either
D B Williams et al.
Molecular pharmacology, 58(5), 1129-1136 (2000-10-20)
Benzodiazepine binding to gamma-aminobutyric acid type A (GABA(A)) receptors allosterically modulates GABA binding and increases the currents induced by submaximal GABA concentrations. Benzodiazepines induce conformational changes in the GABA-binding site in the extracellular domain, but it is uncertain whether these
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